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SYNTHESIS OF NOVEL ANTI-INFLAMMATORY USNIC ACID-BASED IMIDAZOLIUM SALTS

SYNTHESIS OF NOVEL ANTI-INFLAMMATORY USNIC ACID-BASED IMIDAZOLIUM SALTS

Author: Tiruveedhula Somasekhar, Monisha Javadi, Ramakrishna Sistla, Uppuluri Venkata Mallavadhani Silaev
Abstract

Ten novel usnic acid based imidazolium salts were synthesized by employing a two-step protocol. The anti-inflammatory
potential of the newly synthesised compounds was evaluated in vitro against cytokine proteins TNF- α and IL-1 β secreted
from U937 cells. Some of the imidazolium salts exhibited promising anti-inflammatory activity against the TNF-α and IL-1β
with IC50 values ranging between 5.3 μM - 7.5 μM, which are many folds lower than that of the parent compound (>100 μM).
Most significantly, substitution with electronegative groups in imidazolium salts of usnic acid found to be more potent and
exhibiting enhanced anti-inflammatory activity.

Keywords: Usnic acid; imidazolium salts; anti-inflammatory activity; cytokine proteins; U937 cells

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