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AN EXPEDITIOUS AND GREEN APPROACH FOR THE SYNTHESIS OF 2-AMINO-4H-CHROMENES USING A CATALYST OF NATURAL ORIGIN

AN EXPEDITIOUS AND GREEN APPROACH FOR THE SYNTHESIS OF 2-AMINO-4H-CHROMENES USING A CATALYST OF NATURAL ORIGIN

Author: H. D. Bhosale, S. U. Shisodia, R. D. Ingle, P. S. Kendrekar, A. U. Shisodia, László Kótai, R. P. Pawar
Abstract

A highly efficient three-component one step system for the synthesis of 2-amino-4H-chromens is developed. Excellent yields were obtained simply by mixing malononitrile, aromatic aldehyde and α-napthol in lemon juice as a catalyst of natural origin and solvent, avoiding using hazardous organic solvents. The main advantages of this method are its green method character, short reaction time and simple workup procedures and the lack of using any metal containing catalysts.

Keywords: Green synthesis; benzaldehyde; malononitrile; catalyst of natural origin; ultrasound; 2-amino-4H-chromenes

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