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LOWBUSH BLUEBERRY EXTRACT PROTECTS NORMAL HUMAN (HOMO SAPIENS L.) EPIDERMAL KERATINOCYTES FROM DAMAGE BY UV-B IRRADIATION

LOWBUSH BLUEBERRY EXTRACT PROTECTS NORMAL HUMAN (HOMO SAPIENS L.) EPIDERMAL KERATINOCYTES FROM DAMAGE BY UV-B IRRADIATION

Author: Seiji Yamasaki,Kenji Mizoguchi, Naohiro Kodama, Joji Iseki
Abstract

To search for natural materials that protect human skin from damage caused by ultraviolet-B (UV-B) irradiation, we prepared water extracts of the following four dry berries: lowbush blueberry (LBB) (Vaccinium angustifolium L.), highbush blueberry (HBB) (Vaccinium
corymbosum L.), cranberry (CB) (Vaccinium macrocarpon Ait.) and grape (Vitis vinifera L.). Normal human epidermal keratinocytes
(NHEKs) were pretreated with each of the extracts and then subjected to transient UV-B irradiation (15.0 W m-2) for 80 s. The results
showed that pretreatment of NHEKs with LBB extract significantly attenuated UV-B-induced damage. The concentrations of
proanthocyanidins, total flavonoids and total polyphenols in LBB extract were higher than those in the other three berry extracts. Therefore,these compounds might mediate the protection of NHEKs from UV-B-induced damage.

Keywords: flavonoids, normal human epidermal keratinocytes (NHEKs), polyphenols, proanthocyanidins, ultraviolet-B (UV-B)

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