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SYNTHESIS AND ANTI-PROLIFERATIVE SCREENING OF NEWTHIAZOLE COMPOUNDS

SYNTHESIS AND ANTI-PROLIFERATIVE SCREENING OF NEWTHIAZOLE COMPOUNDS

Author: J. P. Sonar, S. D. Pardeshi, S. A. Dokhe, K. R. Kharat, A. M. Zine, László Kótai, R. P. Pawar, S. N. Thore
Abstract

A new series of thiazole compounds are synthesized and theirs anticancer activity was tested against breast cancer cells MCF7. The starting ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate was alkylated by alkyl bromides in DMF. The resulted ethyl 4-methyl-2-(4-(alkyloxy)phenyl)thiazole-5-carboxylate compounds were refluxed with hydrazine hydrate in ethanol to afford 4-methyl-2-(4-(alkyloxy)phenyl)thiazole-5-carbohydrazide compounds. These hydrazides were reacted with various cyclizing reagents to give various 1,3,4-oxadiazole and pyrazole-ring containing thiazole compounds. The antiproliferative activity was calculated on the basis of IC50 values. The (5-amino-3-phenyl-1H-pyrazol-1-yl)(4-methyl-2-(4-(ethoxy)phenyl)thiazol-5-yl)methanone has comparable activity with standard Paclitaxel.

Keywords: Synthesis, anti-proliferative, thiazole, oxadiazole, pyrazole

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