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A NEW KEY FOR OLD LOCK: GLYCEROL, AS AN OH-ACID, CATALYZED ONE-POT THREE-COMPONENT AND FULLY GREEN SYNTHESIS OF 3,4-DIHYDROPYRIMIDIN-2(1H)-ONE AND -THIONES

A NEW KEY FOR OLD LOCK: GLYCEROL, AS AN OH-ACID, CATALYZED ONE-POT THREE-COMPONENT AND FULLY GREEN SYNTHESIS OF 3,4-DIHYDROPYRIMIDIN-2(1H)-ONE AND -THIONES

Author: S. Golshani Anvar, F. K. Behbahani
Abstract

Synthesis of 3,4-dihydropyrimidin-2(1H)-one and 3,4-dihydropyrimidin-2(1H)-thione derivatives from aldehydes, ethyl acetoacetate and
urea or thiourea using glycerol as an organo OH-acid, green and reusable catalyst is reported. The practical and simple protocol led to
excellent yields of the dihydropyrimidin-2(1H)-one and thiones under mild reaction conditions and within short span of reaction times with easy reaction workup by maintaining excellent atom economy.

Keywords: Organic OH-acid, reusable catalyst, glycerol, dihydropyrimidin-2(1H)thione, dihydropyrimidin-2(1H)one.

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