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EATON’S REAGENT CATALYZED SYNTHESIS, IN VITRO αAMYLASE INHIBITORY ACTIVITY AND MOLECULAR DOCKING STUDY OF SOME SCHIFF’S BASES AS DIABETIC-II INHIBITORS

EATON’S REAGENT CATALYZED SYNTHESIS, IN VITRO αAMYLASE INHIBITORY ACTIVITY AND MOLECULAR DOCKING STUDY OF SOME SCHIFF’S BASES AS DIABETIC-II INHIBITORS

Author: Sushama Kauthale, Sunil Tekale, Ambadas Rode, Rajesh Patil, Jaiprakash Sangshetti, László Kótai, Rajendra Pawar
Abstract

A series of Schiff’s bases of p-tolylsulphonyl hydrazide were synthesized by using Eaton's reagent under solvent-free condition,
characterized by spectroscopic data and for evaluated α-amylase inhibitory activity in vitro. Four among the studied compounds exhibited
varying degrees of α-amylase inhibitory activity with IC50 values in the range of 115.48 to 169.42 µg mL-1. The observed results were
supported by the molecular docking study performed to understand the binding interaction of the title compounds with the active site of αamylase enzyme. Results suggest that Schiff's bases of p-tolylsulphonyl hydrazide derivatives can act as potential antidiabetic drugs.

Keywords: α-Amylase, Eaton's reagent, Schiff's bases, Solvent-free, Molecular docking

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