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ONE POT, FOUR-COMPONENT SYNTHESIS 2-AMINO-6-(1,4- DIOXO-3,4-DIHYDROPHTHALAZIN-2(1H)-YL)-4-ARYL-4HPYRAN-3,5-DICARBONITRILES IN AN IONIC LIQU

ONE POT, FOUR-COMPONENT SYNTHESIS 2-AMINO-6-(1,4- DIOXO-3,4-DIHYDROPHTHALAZIN-2(1H)-YL)-4-ARYL-4HPYRAN-3,5-DICARBONITRILES IN AN IONIC LIQU

Author: D. P. Loka Maheshwari B. Satyanarayana
Abstract

[DBUH][OAc] (1,8-diazabicyclo[5.4.0]-undec-7-en-8-ium acetate) mediated, green synthesis of 2-amino-6-(1,4-dioxo-3,4-
dihydrophthalazin-2(1H)-yl)-4-aryl-4H-pyran-3,5-dicarbonitriles have been synthesized by condensing diethyl phthalate, ethyl
cyanohydrazide, benzaldehydes and malononitrile in [DBUH][OAc] medium, at 60-65 oC for 2 h. Particularly valuable features of this
method include high yield, broad substrate scope, shorter reaction times and straightforward procedure

Keywords: : Diethyl phthalate, benzaldehydes, ethyl cyanohydrazide active methylene compounds; 1,8-diazabicyclo[5.4.0]-undec-7- en-8-ium acetate

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