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ONE POT MULTICOMPONENT SYNTHESIS OF FUNCTIONALIZED PYRIDINES USING MORPHOLINE ORGANOBASE AT AMBIENT TEMPERATURE

ONE POT MULTICOMPONENT SYNTHESIS OF FUNCTIONALIZED PYRIDINES USING MORPHOLINE ORGANOBASE AT AMBIENT TEMPERATURE

Author: Sushama S. Kauthale, Sunil U. Tekale, Vijay P. Pagore, Kishor G. Huge, Rajendra P. Pawar
Abstract

An atom efficient synthesis of polysubstituted dihydropyridine derivatives was accomplished by the one-pot four-component condensation of aldehydes, amines, dialkyl acetylene dicarboxylates and active methylene group-containing compounds such as malononitrile or ethyl cyanoacetate using morpholine as a catalyst at ambient temperature. Broad substrate scope, non chromatographic purification, good yields of the products makes it be a useful and valuable methodology for employing the 1,4-dipolar intermediates in synthetic organic chemistry. Use of organobase as a single catalyst, room temperature conditions renders the method protocol as a significant addition to the existing methods for the synthesis of multifunctionalized dihydropyridines.

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