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SILICA SUPPORTED POLYPHOSPHORIC ACID CATALYZED SYNTHESIS OF SUBSTITUTED INDAZOLES

SILICA SUPPORTED POLYPHOSPHORIC ACID CATALYZED SYNTHESIS OF SUBSTITUTED INDAZOLES

Author: S. V. Raut, B. K. Dhotre, S. P. More, A. D. Tidke, Pathan Mohd Arif
Abstract

A clean and straightforward methodology developed for the synthesis of substituted indazoles using silica supported polyphosphoric acid (PPA-SiO2) catalyzed condensation reaction between substituted 2-hydroxybenzaldehydes or acetophenones and hydrazine hydrate or phenylhydrazine. The reaction conditions are optimized for different solvents at different temperatures. The yield of the products improved to 88 to 90 % using silica supported polyphosphoric acid as a catalyst, which is reusable, cost-effective and straightforward to synthesize.

Keywords: : silica supported polyphosphoric acid; hydrazine hydrate; phenyl hydrazine; o-hydroxyacetophenones; indazole

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