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SYNTHESIS AND ANTICANCER EVALUATION OF NEW BENZENESULFONAMIDE DERIVATIVES

SYNTHESIS AND ANTICANCER EVALUATION OF NEW BENZENESULFONAMIDE DERIVATIVES

Author: Rohini N. Shelke, [a] Dattatraya N. Pansare,*[b] Chandraknat D. Pawar, [c] Mininath C. Khade,[a] Vrushali N. Jadhav,[a] Satish U. Deshmukh, [b] Ajit K. Dhas, [b] Pravin N. Chavan, [d] Aniket P. Sarkate, [c] Rajendra P. Pawar, [b] Devanand B. Shinde[e] and
Abstract

A highly efficient protocol was developed for the synthesis of 3-(indoline-1-carbonyl)-N-(substituted)benzenesulfonamide compounds with excellent yields. The in vitro anticancer activity of the new 3-(indoline-1-carbonyl)-N-(substituted)benzenesulfonamide derivatives against A549 (lung cancer cell), HeLa (cervical), MCF-7 (breast cancer cell) and Du-145 (prostate cancer cell) cell lines were studied. Most of the tested compounds showed anticancer activity (IC50 values ranged between 1.98 and 9.12 µM against different cell lines).

Keywords: Indoline; sulfonamides; anticancer activity

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