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SYNTHESIS OF 5-SUBSTITUTED-1,3,4-OXADIAZOLE CLUBBED PYRAZOLE AND DIHYDROPYRIMIDINE DERIVATIVES AS POTENT BIOACTIVE AGENTS

SYNTHESIS OF 5-SUBSTITUTED-1,3,4-OXADIAZOLE CLUBBED PYRAZOLE AND DIHYDROPYRIMIDINE DERIVATIVES AS POTENT BIOACTIVE AGENTS

Author: Bonny Y. Patel, Tushar J. Karkar, Malay J. Bhatt
Abstract

A series of 4-fluorophenylpyrazole clubbed 1,3,4-oxadiazole and 3,4-dihydropyrimidin-2(1H)-ones were prepared by cyclization of
Biginelli-type adducts. Their structures were assigned on the basis of known spectral techniques. All the scaffolds were evaluated for in
vitro antimicrobial activity by broth microdilution bioassay method and in vitro antitubercular property by microplate alamar blue assay
method. Compounds 3j and 3l containing -OH and -CH3 groups were found to act as potent antimicrobials and antitubercular candidates
with relatively low cytotoxicity on VERO cells.

Keywords: Pyrazole; 3,4-dihydropyrimidin-2(1H)-one; 1,3,4-Oxadiazole; Antimicrobial; Antitubercular; MIC

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