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WATER MEDIATED ONE-POT, FOUR COMPONENT SYNTHESIS OF 3,3-DIMETHYL-13-ARYL-3,4-DIHYDRO-1HINDAZOLO[1,2-b]PHTHALAZINE-1,6,11(2H,13H)-TRIONES

WATER MEDIATED ONE-POT, FOUR COMPONENT SYNTHESIS OF 3,3-DIMETHYL-13-ARYL-3,4-DIHYDRO-1HINDAZOLO[1,2-b]PHTHALAZINE-1,6,11(2H,13H)-TRIONES

Author: G. Purna Chander Rao, V. Ramesh, D. Ramachandran, A. Kalyan Chakravarthy
Abstract

Water mediated one-pot, four-component synthesis of substituted 2H-indazolo[2,1-b]phthalazine-triones from dimethyl phthalate,
hydrazine, dimedone and aromatic aldehydes have been reported in the presence of p-toluenesulfonic acid (PTSA) as catalyst at 100 °C for 1.5-2.0 h. This methodology offers several advantages such as good yields, short reaction time, simple procedure, mild condition and
environmentally begins.

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