E-ISSN 2063-5346
 

Research Article 
ECB. 2020; 9(7): 154-159


ONE-POT SYNTHESIS OF PHTHALAZINYL-2-CARBONITRILE INDOLE DERIVATIVES VIA [BMIM][OH] AS IONIC LIQUID AND THEIR ANTI CANCER EVALUATION AND MOLECULAR MODELING STUDIES

Sindhu Hasthavaram, N. Amarnath Reddy, K. Kamala, Raveendra Dayam, K. V. Saritha[.

Abstract
One pot four component, environmentally benign synthesis of 1H-indol-2-yl-5,10-dioxo-5,10-dihydro-1H-pyrazolo[1,2-b]phthalazine-2-carbonitrile derivatives was achieved in the presence of ionic liquid [bmim][OH]. The multi component reaction occurs with an initial formation of pthalazine followed by its reaction with the Knoevenagel cyclocondensation product of indole aldehyde and malononitrile/ethyl cyanoacetate in the presence of [bmim][OH] as ionic liquid at 70-75 oC for 30-45 min. All the synthesized pthalazine indolyl analogues have been tested for their anti-cancer activity on breast and lung carcinoma cell lines. Among the tested derivatives, 5b,5c, 5e, and 5f found to be active against the cancer cell lines. Further, molecular modeling studies were performed to understand binding pattern of the top active molecules with the target protein.

Key words: [bmim][OH]; environmentally benign synthesis; one-pot reaction; indol derivatives.


 
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Pubmed Style

Sindhu Hasthavaram, N. Amarnath Reddy, K. Kamala, Raveendra Dayam, K. V. Saritha[. ONE-POT SYNTHESIS OF PHTHALAZINYL-2-CARBONITRILE INDOLE DERIVATIVES VIA [BMIM][OH] AS IONIC LIQUID AND THEIR ANTI CANCER EVALUATION AND MOLECULAR MODELING STUDIES. ECB. 2020; 9(7): 154-159.


Web Style

Sindhu Hasthavaram, N. Amarnath Reddy, K. Kamala, Raveendra Dayam, K. V. Saritha[. ONE-POT SYNTHESIS OF PHTHALAZINYL-2-CARBONITRILE INDOLE DERIVATIVES VIA [BMIM][OH] AS IONIC LIQUID AND THEIR ANTI CANCER EVALUATION AND MOLECULAR MODELING STUDIES. https://www.eurchembull.com/?mno=47648 [Access: August 09, 2022].


AMA (American Medical Association) Style

Sindhu Hasthavaram, N. Amarnath Reddy, K. Kamala, Raveendra Dayam, K. V. Saritha[. ONE-POT SYNTHESIS OF PHTHALAZINYL-2-CARBONITRILE INDOLE DERIVATIVES VIA [BMIM][OH] AS IONIC LIQUID AND THEIR ANTI CANCER EVALUATION AND MOLECULAR MODELING STUDIES. ECB. 2020; 9(7): 154-159.



Vancouver/ICMJE Style

Sindhu Hasthavaram, N. Amarnath Reddy, K. Kamala, Raveendra Dayam, K. V. Saritha[. ONE-POT SYNTHESIS OF PHTHALAZINYL-2-CARBONITRILE INDOLE DERIVATIVES VIA [BMIM][OH] AS IONIC LIQUID AND THEIR ANTI CANCER EVALUATION AND MOLECULAR MODELING STUDIES. ECB. (2020), [cited August 09, 2022]; 9(7): 154-159.



Harvard Style

Sindhu Hasthavaram, N. Amarnath Reddy, K. Kamala, Raveendra Dayam, K. V. Saritha[ (2020) ONE-POT SYNTHESIS OF PHTHALAZINYL-2-CARBONITRILE INDOLE DERIVATIVES VIA [BMIM][OH] AS IONIC LIQUID AND THEIR ANTI CANCER EVALUATION AND MOLECULAR MODELING STUDIES. ECB, 9 (7), 154-159.



Turabian Style

Sindhu Hasthavaram, N. Amarnath Reddy, K. Kamala, Raveendra Dayam, K. V. Saritha[. 2020. ONE-POT SYNTHESIS OF PHTHALAZINYL-2-CARBONITRILE INDOLE DERIVATIVES VIA [BMIM][OH] AS IONIC LIQUID AND THEIR ANTI CANCER EVALUATION AND MOLECULAR MODELING STUDIES. European Chemical Bulletin, 9 (7), 154-159.



Chicago Style

Sindhu Hasthavaram, N. Amarnath Reddy, K. Kamala, Raveendra Dayam, K. V. Saritha[. "ONE-POT SYNTHESIS OF PHTHALAZINYL-2-CARBONITRILE INDOLE DERIVATIVES VIA [BMIM][OH] AS IONIC LIQUID AND THEIR ANTI CANCER EVALUATION AND MOLECULAR MODELING STUDIES." European Chemical Bulletin 9 (2020), 154-159.



MLA (The Modern Language Association) Style

Sindhu Hasthavaram, N. Amarnath Reddy, K. Kamala, Raveendra Dayam, K. V. Saritha[. "ONE-POT SYNTHESIS OF PHTHALAZINYL-2-CARBONITRILE INDOLE DERIVATIVES VIA [BMIM][OH] AS IONIC LIQUID AND THEIR ANTI CANCER EVALUATION AND MOLECULAR MODELING STUDIES." European Chemical Bulletin 9.7 (2020), 154-159. Print.



APA (American Psychological Association) Style

Sindhu Hasthavaram, N. Amarnath Reddy, K. Kamala, Raveendra Dayam, K. V. Saritha[ (2020) ONE-POT SYNTHESIS OF PHTHALAZINYL-2-CARBONITRILE INDOLE DERIVATIVES VIA [BMIM][OH] AS IONIC LIQUID AND THEIR ANTI CANCER EVALUATION AND MOLECULAR MODELING STUDIES. European Chemical Bulletin, 9 (7), 154-159.