E-ISSN 2063-5346
 

Original Article 
ECB. 2021; 10(3): 134-138


SYNTHESIS of (Z)-N'-(PHENYL(PYRIDIN-2-YL)METHYLENE)NICOTINOHYDRAZIDE: STRUCTURAL CHARACTERIZATION and ANTIOXIDANT ACTIVITY SCREENING

A. Guèye, Papa Sambra Camara, F. Faye, A. Gaye, F. Tamboura, N. Gruber, M. Gaye.

Abstract
Asymmetrical ligand (Z)-N'-(phenyl(pyridin-2-yl)methylene)nicotinohydrazide (I) was synthesized from the condensation of nicotinic acid hydrazide with 2-benzoylpyridine. The compound was characterized by physicochemical analyses, elemental analysis, FTIR, 1H and 13C NMR spectroscopy techniques. The structure of the compound was determined by a single-crystal X-ray diffraction study. The ligand crystallizes in the triclinic space group P-1 with the following unit cell parameters: a = 8.2699 (11) Å, b = 8.6514 (8) Å, c = 11.583 (11) Å, a = 91.308 (3)°, b = 94.155 (5)°, g = 109.008 (4)°, V = 755.17 (14) Å3, Z = 2, R1 = 0.050, wR2 = 0.145. The carbonohydrazone moiety of the molecule is slightly twisted as reflected by the torsion angles values of -1.2 (2)° [O1—C13—N3—N2]. The dihedral angle between the mean planes of the pyridine rings is 11.799 (9)°. The crystal packing of compound (I) is stabilized by intramolecular N(carbohydrazide)–H···N(pyridine) and intermolecular C(phenyl)–H···O(amide) and C(phenyl)–H···N(hydrazino) hydrogen bonds, leading to the formation of sheets parallel to ac plane. The compound screened for antioxidant activity showed variable DPPH inhibition value for different concentrations of DPPH solution.

Key words: 2-benzoylpyridine; IR and NMR spectroscopy; Nicotinohydrazide; Single-crystal X-ray diffraction


 
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How to Cite this Article
Pubmed Style

A. Guèye, Papa Sambra Camara, F. Faye, A. Gaye, F. Tamboura, N. Gruber, M. Gaye. SYNTHESIS of (Z)-N'-(PHENYL(PYRIDIN-2-YL)METHYLENE)NICOTINOHYDRAZIDE: STRUCTURAL CHARACTERIZATION and ANTIOXIDANT ACTIVITY SCREENING. ECB. 2021; 10(3): 134-138.


Web Style

A. Guèye, Papa Sambra Camara, F. Faye, A. Gaye, F. Tamboura, N. Gruber, M. Gaye. SYNTHESIS of (Z)-N'-(PHENYL(PYRIDIN-2-YL)METHYLENE)NICOTINOHYDRAZIDE: STRUCTURAL CHARACTERIZATION and ANTIOXIDANT ACTIVITY SCREENING. https://www.eurchembull.com/?mno=52045 [Access: September 25, 2022].


AMA (American Medical Association) Style

A. Guèye, Papa Sambra Camara, F. Faye, A. Gaye, F. Tamboura, N. Gruber, M. Gaye. SYNTHESIS of (Z)-N'-(PHENYL(PYRIDIN-2-YL)METHYLENE)NICOTINOHYDRAZIDE: STRUCTURAL CHARACTERIZATION and ANTIOXIDANT ACTIVITY SCREENING. ECB. 2021; 10(3): 134-138.



Vancouver/ICMJE Style

A. Guèye, Papa Sambra Camara, F. Faye, A. Gaye, F. Tamboura, N. Gruber, M. Gaye. SYNTHESIS of (Z)-N'-(PHENYL(PYRIDIN-2-YL)METHYLENE)NICOTINOHYDRAZIDE: STRUCTURAL CHARACTERIZATION and ANTIOXIDANT ACTIVITY SCREENING. ECB. (2021), [cited September 25, 2022]; 10(3): 134-138.



Harvard Style

A. Guèye, Papa Sambra Camara, F. Faye, A. Gaye, F. Tamboura, N. Gruber, M. Gaye (2021) SYNTHESIS of (Z)-N'-(PHENYL(PYRIDIN-2-YL)METHYLENE)NICOTINOHYDRAZIDE: STRUCTURAL CHARACTERIZATION and ANTIOXIDANT ACTIVITY SCREENING. ECB, 10 (3), 134-138.



Turabian Style

A. Guèye, Papa Sambra Camara, F. Faye, A. Gaye, F. Tamboura, N. Gruber, M. Gaye. 2021. SYNTHESIS of (Z)-N'-(PHENYL(PYRIDIN-2-YL)METHYLENE)NICOTINOHYDRAZIDE: STRUCTURAL CHARACTERIZATION and ANTIOXIDANT ACTIVITY SCREENING. European Chemical Bulletin, 10 (3), 134-138.



Chicago Style

A. Guèye, Papa Sambra Camara, F. Faye, A. Gaye, F. Tamboura, N. Gruber, M. Gaye. "SYNTHESIS of (Z)-N'-(PHENYL(PYRIDIN-2-YL)METHYLENE)NICOTINOHYDRAZIDE: STRUCTURAL CHARACTERIZATION and ANTIOXIDANT ACTIVITY SCREENING." European Chemical Bulletin 10 (2021), 134-138.



MLA (The Modern Language Association) Style

A. Guèye, Papa Sambra Camara, F. Faye, A. Gaye, F. Tamboura, N. Gruber, M. Gaye. "SYNTHESIS of (Z)-N'-(PHENYL(PYRIDIN-2-YL)METHYLENE)NICOTINOHYDRAZIDE: STRUCTURAL CHARACTERIZATION and ANTIOXIDANT ACTIVITY SCREENING." European Chemical Bulletin 10.3 (2021), 134-138. Print.



APA (American Psychological Association) Style

A. Guèye, Papa Sambra Camara, F. Faye, A. Gaye, F. Tamboura, N. Gruber, M. Gaye (2021) SYNTHESIS of (Z)-N'-(PHENYL(PYRIDIN-2-YL)METHYLENE)NICOTINOHYDRAZIDE: STRUCTURAL CHARACTERIZATION and ANTIOXIDANT ACTIVITY SCREENING. European Chemical Bulletin, 10 (3), 134-138.