E-ISSN 2063-5346
 

Original Article 
ECB. 2021; 10(3): 139-146


NEW 1,3,4-OXADIAZOLE BASED SCHIFF BASE DERIVATIVES: SYNTHESIS, CHARACTERIZATION AND ANTIBACTERIAL ACTIVITY ALONG WITH IN SILICO STUDIES

Lalpara J.N., Hadiyal S.D., Dhalani J.M., Dubal G.G.

Abstract
A series of novel 1,3,4-oxadiazole based Schiff base derivatives were designed and synthesized using the efficient strategy with excellent yields. Synthesized molecules evaluated in vitro antibacterial studies in contradiction of microorganisms, namely Escherichia coli, Klebsiella pneumoniae, Bacillus subtilis, and Bacillus megaterium. The bioassay result revealed that most of tested compounds good to moderate inhibition against microorganisms. Some among them show excellent inhibitory effects towards the Gram-positive and Gram-negative bacteria. Besides, the drug-likeness, lipophilicity and cytotoxicity.

Key words: 4-oxadiazole; Antimicrobial; Cytotoxicity; Drug-likeness; Schiff base


 
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How to Cite this Article
Pubmed Style

Lalpara J.N., Hadiyal S.D., Dhalani J.M., Dubal G.G. NEW 1,3,4-OXADIAZOLE BASED SCHIFF BASE DERIVATIVES: SYNTHESIS, CHARACTERIZATION AND ANTIBACTERIAL ACTIVITY ALONG WITH IN SILICO STUDIES. ECB. 2021; 10(3): 139-146.


Web Style

Lalpara J.N., Hadiyal S.D., Dhalani J.M., Dubal G.G. NEW 1,3,4-OXADIAZOLE BASED SCHIFF BASE DERIVATIVES: SYNTHESIS, CHARACTERIZATION AND ANTIBACTERIAL ACTIVITY ALONG WITH IN SILICO STUDIES. https://www.eurchembull.com/?mno=52051 [Access: September 25, 2022].


AMA (American Medical Association) Style

Lalpara J.N., Hadiyal S.D., Dhalani J.M., Dubal G.G. NEW 1,3,4-OXADIAZOLE BASED SCHIFF BASE DERIVATIVES: SYNTHESIS, CHARACTERIZATION AND ANTIBACTERIAL ACTIVITY ALONG WITH IN SILICO STUDIES. ECB. 2021; 10(3): 139-146.



Vancouver/ICMJE Style

Lalpara J.N., Hadiyal S.D., Dhalani J.M., Dubal G.G. NEW 1,3,4-OXADIAZOLE BASED SCHIFF BASE DERIVATIVES: SYNTHESIS, CHARACTERIZATION AND ANTIBACTERIAL ACTIVITY ALONG WITH IN SILICO STUDIES. ECB. (2021), [cited September 25, 2022]; 10(3): 139-146.



Harvard Style

Lalpara J.N., Hadiyal S.D., Dhalani J.M., Dubal G.G (2021) NEW 1,3,4-OXADIAZOLE BASED SCHIFF BASE DERIVATIVES: SYNTHESIS, CHARACTERIZATION AND ANTIBACTERIAL ACTIVITY ALONG WITH IN SILICO STUDIES. ECB, 10 (3), 139-146.



Turabian Style

Lalpara J.N., Hadiyal S.D., Dhalani J.M., Dubal G.G. 2021. NEW 1,3,4-OXADIAZOLE BASED SCHIFF BASE DERIVATIVES: SYNTHESIS, CHARACTERIZATION AND ANTIBACTERIAL ACTIVITY ALONG WITH IN SILICO STUDIES. European Chemical Bulletin, 10 (3), 139-146.



Chicago Style

Lalpara J.N., Hadiyal S.D., Dhalani J.M., Dubal G.G. "NEW 1,3,4-OXADIAZOLE BASED SCHIFF BASE DERIVATIVES: SYNTHESIS, CHARACTERIZATION AND ANTIBACTERIAL ACTIVITY ALONG WITH IN SILICO STUDIES." European Chemical Bulletin 10 (2021), 139-146.



MLA (The Modern Language Association) Style

Lalpara J.N., Hadiyal S.D., Dhalani J.M., Dubal G.G. "NEW 1,3,4-OXADIAZOLE BASED SCHIFF BASE DERIVATIVES: SYNTHESIS, CHARACTERIZATION AND ANTIBACTERIAL ACTIVITY ALONG WITH IN SILICO STUDIES." European Chemical Bulletin 10.3 (2021), 139-146. Print.



APA (American Psychological Association) Style

Lalpara J.N., Hadiyal S.D., Dhalani J.M., Dubal G.G (2021) NEW 1,3,4-OXADIAZOLE BASED SCHIFF BASE DERIVATIVES: SYNTHESIS, CHARACTERIZATION AND ANTIBACTERIAL ACTIVITY ALONG WITH IN SILICO STUDIES. European Chemical Bulletin, 10 (3), 139-146.