E-ISSN 2063-5346
 

Research Article 
ECB. 2021; 10(3): 147-154


SYNTHESIS, ANTICANCER and ANTIOXIDANT PROPERTIES of SOME 4-THIOXO-THIAZOLIDIN-2-ONES

Chulovska Z., Drapak I., Chaban T., Ogurtsov V., Chaban I.,Matiychuk V.

Abstract
The synthesis of some 4-thioxothiazolidin-2-ones based on the azo coupling reaction was carried out. Obtained substance structures were confirmed by means of 1H NMR spectroscopy and elemental analysis. Newly synthesized compounds were selected by the National Cancer Institute (NCI) Developmental Therapeutic Program for the in vitro cell line screening to explore their anticancer activity. The antioxidant activity of the synthesized compounds was measured in vitro on 2,2-diphenyl-1-picrylhydrazyl (DPPH) radicals by means of the scavenging effect method. Anticancer and antioxidant activities among 5-(aryl-hydrazono)-4-thioxothiazolidin-2-ones were idenfied for the first time.

Key words: 4-thioxothiazolidin-2-ones; Anticancer activity; Antioxidant activity; Azo coupling; Organic synthesis


 
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How to Cite this Article
Pubmed Style

Chulovska Z., Drapak I., Chaban T., Ogurtsov V., Chaban I.,Matiychuk V. SYNTHESIS, ANTICANCER and ANTIOXIDANT PROPERTIES of SOME 4-THIOXO-THIAZOLIDIN-2-ONES. ECB. 2021; 10(3): 147-154.


Web Style

Chulovska Z., Drapak I., Chaban T., Ogurtsov V., Chaban I.,Matiychuk V. SYNTHESIS, ANTICANCER and ANTIOXIDANT PROPERTIES of SOME 4-THIOXO-THIAZOLIDIN-2-ONES. https://www.eurchembull.com/?mno=52054 [Access: September 25, 2022].


AMA (American Medical Association) Style

Chulovska Z., Drapak I., Chaban T., Ogurtsov V., Chaban I.,Matiychuk V. SYNTHESIS, ANTICANCER and ANTIOXIDANT PROPERTIES of SOME 4-THIOXO-THIAZOLIDIN-2-ONES. ECB. 2021; 10(3): 147-154.



Vancouver/ICMJE Style

Chulovska Z., Drapak I., Chaban T., Ogurtsov V., Chaban I.,Matiychuk V. SYNTHESIS, ANTICANCER and ANTIOXIDANT PROPERTIES of SOME 4-THIOXO-THIAZOLIDIN-2-ONES. ECB. (2021), [cited September 25, 2022]; 10(3): 147-154.



Harvard Style

Chulovska Z., Drapak I., Chaban T., Ogurtsov V., Chaban I.,Matiychuk V (2021) SYNTHESIS, ANTICANCER and ANTIOXIDANT PROPERTIES of SOME 4-THIOXO-THIAZOLIDIN-2-ONES. ECB, 10 (3), 147-154.



Turabian Style

Chulovska Z., Drapak I., Chaban T., Ogurtsov V., Chaban I.,Matiychuk V. 2021. SYNTHESIS, ANTICANCER and ANTIOXIDANT PROPERTIES of SOME 4-THIOXO-THIAZOLIDIN-2-ONES. European Chemical Bulletin, 10 (3), 147-154.



Chicago Style

Chulovska Z., Drapak I., Chaban T., Ogurtsov V., Chaban I.,Matiychuk V. "SYNTHESIS, ANTICANCER and ANTIOXIDANT PROPERTIES of SOME 4-THIOXO-THIAZOLIDIN-2-ONES." European Chemical Bulletin 10 (2021), 147-154.



MLA (The Modern Language Association) Style

Chulovska Z., Drapak I., Chaban T., Ogurtsov V., Chaban I.,Matiychuk V. "SYNTHESIS, ANTICANCER and ANTIOXIDANT PROPERTIES of SOME 4-THIOXO-THIAZOLIDIN-2-ONES." European Chemical Bulletin 10.3 (2021), 147-154. Print.



APA (American Psychological Association) Style

Chulovska Z., Drapak I., Chaban T., Ogurtsov V., Chaban I.,Matiychuk V (2021) SYNTHESIS, ANTICANCER and ANTIOXIDANT PROPERTIES of SOME 4-THIOXO-THIAZOLIDIN-2-ONES. European Chemical Bulletin, 10 (3), 147-154.