E-ISSN 2063-5346
 

Original Article 
ECB. 2014; 3(4): 358-361


BIOLOGICAL EVALUATION OF PYRAZINAMIDE DERIVATIVES AS AN ANTICANCER CLASS

Felipe A. R. Rodrigues, Igor da S. Bomfim, Bruno C. Cavalcanti, Claudia Ó Pessoa, Alessandra C. Pinheiro, Camilo H. S. Lima, Marcus V. N. de Souza.

Abstract
A series of fifty one pyrazinyl derivatives have been synthesized and evaluated for their activity against four cancer cell lines, exhibiting good citotoxicity (IC50 ranging from 1.1 to 5.6 μg mL-1). The structure-activity relationship (SAR) analysis indicated that the hydroxyl group located in ortho position is critical for the biological activity of these compounds. The presence of hydroxyl groups on benzene ring plays an important role in the anticancer activity of this series, feature especially observed in disubstituted derivatives.

Key words: antitumor activity, pyrazinamide, hydrazones, drugs


 
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How to Cite this Article
Pubmed Style

Felipe A. R. Rodrigues, Igor da S. Bomfim, Bruno C. Cavalcanti, Claudia Ó Pessoa, Alessandra C. Pinheiro, Camilo H. S. Lima, Marcus V. N. de Souza. BIOLOGICAL EVALUATION OF PYRAZINAMIDE DERIVATIVES AS AN ANTICANCER CLASS. ECB. 2014; 3(4): 358-361.


Web Style

Felipe A. R. Rodrigues, Igor da S. Bomfim, Bruno C. Cavalcanti, Claudia Ó Pessoa, Alessandra C. Pinheiro, Camilo H. S. Lima, Marcus V. N. de Souza. BIOLOGICAL EVALUATION OF PYRAZINAMIDE DERIVATIVES AS AN ANTICANCER CLASS. https://www.eurchembull.com/?mno=55642 [Access: August 09, 2022].


AMA (American Medical Association) Style

Felipe A. R. Rodrigues, Igor da S. Bomfim, Bruno C. Cavalcanti, Claudia Ó Pessoa, Alessandra C. Pinheiro, Camilo H. S. Lima, Marcus V. N. de Souza. BIOLOGICAL EVALUATION OF PYRAZINAMIDE DERIVATIVES AS AN ANTICANCER CLASS. ECB. 2014; 3(4): 358-361.



Vancouver/ICMJE Style

Felipe A. R. Rodrigues, Igor da S. Bomfim, Bruno C. Cavalcanti, Claudia Ó Pessoa, Alessandra C. Pinheiro, Camilo H. S. Lima, Marcus V. N. de Souza. BIOLOGICAL EVALUATION OF PYRAZINAMIDE DERIVATIVES AS AN ANTICANCER CLASS. ECB. (2014), [cited August 09, 2022]; 3(4): 358-361.



Harvard Style

Felipe A. R. Rodrigues, Igor da S. Bomfim, Bruno C. Cavalcanti, Claudia Ó Pessoa, Alessandra C. Pinheiro, Camilo H. S. Lima, Marcus V. N. de Souza (2014) BIOLOGICAL EVALUATION OF PYRAZINAMIDE DERIVATIVES AS AN ANTICANCER CLASS. ECB, 3 (4), 358-361.



Turabian Style

Felipe A. R. Rodrigues, Igor da S. Bomfim, Bruno C. Cavalcanti, Claudia Ó Pessoa, Alessandra C. Pinheiro, Camilo H. S. Lima, Marcus V. N. de Souza. 2014. BIOLOGICAL EVALUATION OF PYRAZINAMIDE DERIVATIVES AS AN ANTICANCER CLASS. European Chemical Bulletin, 3 (4), 358-361.



Chicago Style

Felipe A. R. Rodrigues, Igor da S. Bomfim, Bruno C. Cavalcanti, Claudia Ó Pessoa, Alessandra C. Pinheiro, Camilo H. S. Lima, Marcus V. N. de Souza. "BIOLOGICAL EVALUATION OF PYRAZINAMIDE DERIVATIVES AS AN ANTICANCER CLASS." European Chemical Bulletin 3 (2014), 358-361.



MLA (The Modern Language Association) Style

Felipe A. R. Rodrigues, Igor da S. Bomfim, Bruno C. Cavalcanti, Claudia Ó Pessoa, Alessandra C. Pinheiro, Camilo H. S. Lima, Marcus V. N. de Souza. "BIOLOGICAL EVALUATION OF PYRAZINAMIDE DERIVATIVES AS AN ANTICANCER CLASS." European Chemical Bulletin 3.4 (2014), 358-361. Print.



APA (American Psychological Association) Style

Felipe A. R. Rodrigues, Igor da S. Bomfim, Bruno C. Cavalcanti, Claudia Ó Pessoa, Alessandra C. Pinheiro, Camilo H. S. Lima, Marcus V. N. de Souza (2014) BIOLOGICAL EVALUATION OF PYRAZINAMIDE DERIVATIVES AS AN ANTICANCER CLASS. European Chemical Bulletin, 3 (4), 358-361.