E-ISSN 2063-5346
 

Research Article 


COMPUTATIONAL INVESTIGATION OF NORFLOXACIN DERIVATIVES PROPERTIES RELATED TO THEIR BIOLOGICAL ACTIVITY

Noor H. Naser*, Sahar A. Hussein, Falah S.A. Suhail.

Abstract
Background: Fluoroquinolones have great efficacy, broad spectrum of activity, used for treatment of several infections, due to miss use and uncontrolled use of antibacterial agents, lead to emergence of bacterial resistance. Therefore new fluoroquinolones derivatives were synthesized and their biological activities were studied according to their some computational properties. Aim: To predict the antibacterial activity of newly synthesized norfloxacin derivatives depending on their computational investigated properties. Material and method: Seven norfloxacin derivatives have been designed; their physical properties have been investigated using quantum chemistry computational methods. Results: There were six descriptions (one electronic, three physicochemical and two geometric) have highly compatible with Norfloxacin derivative activity, can be used to predicts of their activity by using QSAR equation of Norfloxacin derivatives.Conclusion: QSAR would lead to robust equation and predictive models are capable of making accurate and reliable calculations for a new Norfloxacinanalog

Key words: QSARs, DFT, Molecular Properties, GAMESS, Norfloxacin, Antibacterial resistant.


 
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How to Cite this Article
Pubmed Style

Noor H. Naser, Sahar A. Hussein, Falah S.A. Suhail. COMPUTATIONAL INVESTIGATION OF NORFLOXACIN DERIVATIVES PROPERTIES RELATED TO THEIR BIOLOGICAL ACTIVITY. ECB. 2022; 11(3): 1-7. doi:10.31838/ecb/2022.11.03.001


Web Style

Noor H. Naser, Sahar A. Hussein, Falah S.A. Suhail. COMPUTATIONAL INVESTIGATION OF NORFLOXACIN DERIVATIVES PROPERTIES RELATED TO THEIR BIOLOGICAL ACTIVITY. https://www.eurchembull.com/?mno=67252 [Access: August 09, 2022]. doi:10.31838/ecb/2022.11.03.001


AMA (American Medical Association) Style

Noor H. Naser, Sahar A. Hussein, Falah S.A. Suhail. COMPUTATIONAL INVESTIGATION OF NORFLOXACIN DERIVATIVES PROPERTIES RELATED TO THEIR BIOLOGICAL ACTIVITY. ECB. 2022; 11(3): 1-7. doi:10.31838/ecb/2022.11.03.001



Vancouver/ICMJE Style

Noor H. Naser, Sahar A. Hussein, Falah S.A. Suhail. COMPUTATIONAL INVESTIGATION OF NORFLOXACIN DERIVATIVES PROPERTIES RELATED TO THEIR BIOLOGICAL ACTIVITY. ECB. (2022), [cited August 09, 2022]; 11(3): 1-7. doi:10.31838/ecb/2022.11.03.001



Harvard Style

Noor H. Naser, Sahar A. Hussein, Falah S.A. Suhail (2022) COMPUTATIONAL INVESTIGATION OF NORFLOXACIN DERIVATIVES PROPERTIES RELATED TO THEIR BIOLOGICAL ACTIVITY. ECB, 11 (3), 1-7. doi:10.31838/ecb/2022.11.03.001



Turabian Style

Noor H. Naser, Sahar A. Hussein, Falah S.A. Suhail. 2022. COMPUTATIONAL INVESTIGATION OF NORFLOXACIN DERIVATIVES PROPERTIES RELATED TO THEIR BIOLOGICAL ACTIVITY. European Chemical Bulletin, 11 (3), 1-7. doi:10.31838/ecb/2022.11.03.001



Chicago Style

Noor H. Naser, Sahar A. Hussein, Falah S.A. Suhail. "COMPUTATIONAL INVESTIGATION OF NORFLOXACIN DERIVATIVES PROPERTIES RELATED TO THEIR BIOLOGICAL ACTIVITY." European Chemical Bulletin 11 (2022), 1-7. doi:10.31838/ecb/2022.11.03.001



MLA (The Modern Language Association) Style

Noor H. Naser, Sahar A. Hussein, Falah S.A. Suhail. "COMPUTATIONAL INVESTIGATION OF NORFLOXACIN DERIVATIVES PROPERTIES RELATED TO THEIR BIOLOGICAL ACTIVITY." European Chemical Bulletin 11.3 (2022), 1-7. Print. doi:10.31838/ecb/2022.11.03.001



APA (American Psychological Association) Style

Noor H. Naser, Sahar A. Hussein, Falah S.A. Suhail (2022) COMPUTATIONAL INVESTIGATION OF NORFLOXACIN DERIVATIVES PROPERTIES RELATED TO THEIR BIOLOGICAL ACTIVITY. European Chemical Bulletin, 11 (3), 1-7. doi:10.31838/ecb/2022.11.03.001