E-ISSN 2063-5346
 

Original Article 
ECB. 2021; 10(2): 123-127


SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL SCREENING OF PYRIDINE DERIVATIVES INCORPORATED WITH CHALCONE MOTIF

Chirag H. Rathod, Aftab Mithani, Anilkumar S. Patel.

Abstract
Herein we report synthesis of 3-methyl-2-((2-styrylphenoxy)methyl)-4-(2,2,2-trifluoroethoxy)pyridine derivatives (9a-j) from 2-((3-
methyl-4-(2,2,2-trifluoroethoxy)pyridin-2-yl)methoxy)benzaldehyde (7) and appropriate acetophenone (8a-f) afford very good to excellent
yield (80-95 %). The structure of newly synthesized compounds have been established on the basis of 1H-NMR, 13C-NMR, ESI-MS and
elemental analysis. All compounds (9a-f) were screened for their in vitro antibacterial activity against Gram-positive bacteria
(Streptococcus pneumoniae and Bacillus subtilis), Gram-negative bacteria (Escherichia coli and Vibrio cholerae) and antifungal activity
against C. albicans and A. fumigatus by MIC method

Key words: Pyridine derivatives; chalcone; antimicrobial activity; antifungal activity.


 
ARTICLE TOOLS
Abstract
PDF Fulltext
How to cite this articleHow to cite this article
Citation Tools
Related Records
 Articles by Chirag H. Rathod
Articles by Aftab Mithani
Articles by Anilkumar S. Patel
on Google
on Google Scholar

How to Cite this Article
Pubmed Style

Chirag H. Rathod, Aftab Mithani, Anilkumar S. Patel. SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL SCREENING OF PYRIDINE DERIVATIVES INCORPORATED WITH CHALCONE MOTIF. ECB. 2021; 10(2): 123-127.


Web Style

Chirag H. Rathod, Aftab Mithani, Anilkumar S. Patel. SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL SCREENING OF PYRIDINE DERIVATIVES INCORPORATED WITH CHALCONE MOTIF. https://www.eurchembull.com/?mno=83557 [Access: November 29, 2022].


AMA (American Medical Association) Style

Chirag H. Rathod, Aftab Mithani, Anilkumar S. Patel. SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL SCREENING OF PYRIDINE DERIVATIVES INCORPORATED WITH CHALCONE MOTIF. ECB. 2021; 10(2): 123-127.



Vancouver/ICMJE Style

Chirag H. Rathod, Aftab Mithani, Anilkumar S. Patel. SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL SCREENING OF PYRIDINE DERIVATIVES INCORPORATED WITH CHALCONE MOTIF. ECB. (2021), [cited November 29, 2022]; 10(2): 123-127.



Harvard Style

Chirag H. Rathod, Aftab Mithani, Anilkumar S. Patel (2021) SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL SCREENING OF PYRIDINE DERIVATIVES INCORPORATED WITH CHALCONE MOTIF. ECB, 10 (2), 123-127.



Turabian Style

Chirag H. Rathod, Aftab Mithani, Anilkumar S. Patel. 2021. SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL SCREENING OF PYRIDINE DERIVATIVES INCORPORATED WITH CHALCONE MOTIF. European Chemical Bulletin, 10 (2), 123-127.



Chicago Style

Chirag H. Rathod, Aftab Mithani, Anilkumar S. Patel. "SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL SCREENING OF PYRIDINE DERIVATIVES INCORPORATED WITH CHALCONE MOTIF." European Chemical Bulletin 10 (2021), 123-127.



MLA (The Modern Language Association) Style

Chirag H. Rathod, Aftab Mithani, Anilkumar S. Patel. "SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL SCREENING OF PYRIDINE DERIVATIVES INCORPORATED WITH CHALCONE MOTIF." European Chemical Bulletin 10.2 (2021), 123-127. Print.



APA (American Psychological Association) Style

Chirag H. Rathod, Aftab Mithani, Anilkumar S. Patel (2021) SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL SCREENING OF PYRIDINE DERIVATIVES INCORPORATED WITH CHALCONE MOTIF. European Chemical Bulletin, 10 (2), 123-127.