E-ISSN 2063-5346
 

Research Article 


STABILITY AND IN VITRO DRUG RELEASE STUDIES OF NIOSOME VITAMIN D3

Audia Triani Olii, A.K. Nugroho, Ronny Martien, Sugeng Riyanto.

Abstract
This study aimed to determine the stability of niosome vitamin D3 at two different temperatures, room temperature 25oC and 4oC, and to view the in vitro release profile and determine the kinetics model of the release. Niosome is a drug delivery system formed from surfactants and cholesterol in the form of vesicles that entrap drugs in their matrix. This allows the drug trapped in the niosome matrix to be protected from the influence of the biological environment, which can reduce or eliminate drug activity. In addition, in the presence of a vesicle matrix system, it often provides a modified release. From a previous study conducted by Audia et al., vitamin D3 niosome were prepared from Span 60 and cholesterol using the thin layer method. In this study, a stability test was carried out for 30 days at two different storage temperatures, as well as an in vitro study of the release of vitamin D3 niosome to determine the release kinetics model. The results showed that vitamin D3 niosome were more stable at 4oC than at 25oC. The in vitro release test showed the release of vitamin D3 niosome at 3.25 ± 0.2% for 420 minutes with release kinetics following the Korsmeyer-Peppas kinetic model.

Key words: release kinetics, niosome vitamin D3, Korsmeyer-Peppas


 
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How to Cite this Article
Pubmed Style

Audia Triani Olii , A.K. Nugroho , Ronny Martien , Sugeng Riyanto. STABILITY AND IN VITRO DRUG RELEASE STUDIES OF NIOSOME VITAMIN D3. ECB. 2022; 11(11): 140-144. doi:10.31838/ecb/2022.11.11.016


Web Style

Audia Triani Olii , A.K. Nugroho , Ronny Martien , Sugeng Riyanto. STABILITY AND IN VITRO DRUG RELEASE STUDIES OF NIOSOME VITAMIN D3. https://www.eurchembull.com/?mno=132135 [Access: January 21, 2023]. doi:10.31838/ecb/2022.11.11.016


AMA (American Medical Association) Style

Audia Triani Olii , A.K. Nugroho , Ronny Martien , Sugeng Riyanto. STABILITY AND IN VITRO DRUG RELEASE STUDIES OF NIOSOME VITAMIN D3. ECB. 2022; 11(11): 140-144. doi:10.31838/ecb/2022.11.11.016



Vancouver/ICMJE Style

Audia Triani Olii , A.K. Nugroho , Ronny Martien , Sugeng Riyanto. STABILITY AND IN VITRO DRUG RELEASE STUDIES OF NIOSOME VITAMIN D3. ECB. (2022), [cited January 21, 2023]; 11(11): 140-144. doi:10.31838/ecb/2022.11.11.016



Harvard Style

Audia Triani Olii , A.K. Nugroho , Ronny Martien , Sugeng Riyanto (2022) STABILITY AND IN VITRO DRUG RELEASE STUDIES OF NIOSOME VITAMIN D3. ECB, 11 (11), 140-144. doi:10.31838/ecb/2022.11.11.016



Turabian Style

Audia Triani Olii , A.K. Nugroho , Ronny Martien , Sugeng Riyanto. 2022. STABILITY AND IN VITRO DRUG RELEASE STUDIES OF NIOSOME VITAMIN D3. European Chemical Bulletin, 11 (11), 140-144. doi:10.31838/ecb/2022.11.11.016



Chicago Style

Audia Triani Olii , A.K. Nugroho , Ronny Martien , Sugeng Riyanto. "STABILITY AND IN VITRO DRUG RELEASE STUDIES OF NIOSOME VITAMIN D3." European Chemical Bulletin 11 (2022), 140-144. doi:10.31838/ecb/2022.11.11.016



MLA (The Modern Language Association) Style

Audia Triani Olii , A.K. Nugroho , Ronny Martien , Sugeng Riyanto. "STABILITY AND IN VITRO DRUG RELEASE STUDIES OF NIOSOME VITAMIN D3." European Chemical Bulletin 11.11 (2022), 140-144. Print. doi:10.31838/ecb/2022.11.11.016



APA (American Psychological Association) Style

Audia Triani Olii , A.K. Nugroho , Ronny Martien , Sugeng Riyanto (2022) STABILITY AND IN VITRO DRUG RELEASE STUDIES OF NIOSOME VITAMIN D3. European Chemical Bulletin, 11 (11), 140-144. doi:10.31838/ecb/2022.11.11.016