E-ISSN 2063-5346
 

Research Article 
ECB. 2017; 6(8): 359-364


EVALUATION OF DISSOLUTION OF RIFAXIMIN AND ITS IMPORTANCE

Ana Carolina Kogawa, Hérida Regina Nunes Salgado.

Abstract
Rifaximin, an oral antibiotic marketed as tablets, does not have dissolution method described either in official compendiums or literature. This lack of knowledge blinds the real rate of drug availability. Thus, all potentialities of the active principle are not enough if it is trapped in its formulation or it is released erroneously. The absence of dissolution method can reduce the drug to the level of an adjuvant. Therefore, the objective of this study was to develop and validate a successful dissolution method for the evaluation of rifaximin tablets. The method contemplated the parameters for linearity, selectivity, precision, accuracy and robustness. It was found that for the dissolution of the tablets of rifaximin of 200 mg, paddle apparatus at 50 rpm and 900 mL of acetate buffer of pH 5.0 + 0.2 % SLS as dissolution medium are optimum conditions. The method presented is useful and can be applied for the routine quality control of tablets of rifaximin.

Key words: Antibiotic, dissolution, quality control, rifaximin, tablets.


 
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Pubmed Style

Ana Carolina Kogawa, Hérida Regina Nunes Salgado. EVALUATION OF DISSOLUTION OF RIFAXIMIN AND ITS IMPORTANCE. ECB. 2017; 6(8): 359-364.


Web Style

Ana Carolina Kogawa, Hérida Regina Nunes Salgado. EVALUATION OF DISSOLUTION OF RIFAXIMIN AND ITS IMPORTANCE. https://www.eurchembull.com/?mno=42864 [Access: January 21, 2023].


AMA (American Medical Association) Style

Ana Carolina Kogawa, Hérida Regina Nunes Salgado. EVALUATION OF DISSOLUTION OF RIFAXIMIN AND ITS IMPORTANCE. ECB. 2017; 6(8): 359-364.



Vancouver/ICMJE Style

Ana Carolina Kogawa, Hérida Regina Nunes Salgado. EVALUATION OF DISSOLUTION OF RIFAXIMIN AND ITS IMPORTANCE. ECB. (2017), [cited January 21, 2023]; 6(8): 359-364.



Harvard Style

Ana Carolina Kogawa, Hérida Regina Nunes Salgado (2017) EVALUATION OF DISSOLUTION OF RIFAXIMIN AND ITS IMPORTANCE. ECB, 6 (8), 359-364.



Turabian Style

Ana Carolina Kogawa, Hérida Regina Nunes Salgado. 2017. EVALUATION OF DISSOLUTION OF RIFAXIMIN AND ITS IMPORTANCE. European Chemical Bulletin, 6 (8), 359-364.



Chicago Style

Ana Carolina Kogawa, Hérida Regina Nunes Salgado. "EVALUATION OF DISSOLUTION OF RIFAXIMIN AND ITS IMPORTANCE." European Chemical Bulletin 6 (2017), 359-364.



MLA (The Modern Language Association) Style

Ana Carolina Kogawa, Hérida Regina Nunes Salgado. "EVALUATION OF DISSOLUTION OF RIFAXIMIN AND ITS IMPORTANCE." European Chemical Bulletin 6.8 (2017), 359-364. Print.



APA (American Psychological Association) Style

Ana Carolina Kogawa, Hérida Regina Nunes Salgado (2017) EVALUATION OF DISSOLUTION OF RIFAXIMIN AND ITS IMPORTANCE. European Chemical Bulletin, 6 (8), 359-364.