SYNTHESIS AND MOLECULAR DOCKING STUDIES OF NOVEL PYRIDINE-THIAZOLE-HYDRAZONE CONJUGATES AS ANTIMICROBIAL AND ANTIOXIDANT AGENTS

Mahesh B. Muluk; Pravin S. Patil; Sanghratna L. Kasare; Ravibhushan S. Kulkarni; Prashant P. Dixit; Prafulla B. Choudhari; Kishan P. Haval

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Research Article

ECB. 2020; 9(7): 184-192

SYNTHESIS AND MOLECULAR DOCKING STUDIES OF NOVEL PYRIDINE-THIAZOLE-HYDRAZONE CONJUGATES AS ANTIMICROBIAL AND ANTIOXIDANT AGENTS

Mahesh B. Muluk, Pravin S. Patil, Sanghratna L. Kasare, Ravibhushan S. Kulkarni, Prashant P. Dixit, Prafulla B. Choudhari, Kishan P. Haval.

Abstract
In the investigation, a series of new pyridyl and thiazolyl clubbed hydrazone derivatives have been synthesized. The newly synthesized compounds were evaluated for their in vitro antimicrobial and antioxidant activities. Some among the compounds have shown excellent antimicrobial activity against both bacterial and fungal pathogens. Two compounds among the series have exhibited excellent antioxidant activity. Furthermore, a molecular docking study has been performed against DNA gyrase to know the binding modes of these molecules and recorded good binding affinity. The ADME study has also been performed for predicting the pharmacokinetic profile, which expressed good oral drug-like behaviour.

Key words: Antimicrobial activity, antioxidant activity, thiazole, hydrazone, molecular docking study.

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Pubmed Style

Mahesh B. Muluk, Pravin S. Patil, Sanghratna L. Kasare, Ravibhushan S. Kulkarni, Prashant P. Dixit, Prafulla B. Choudhari, Kishan P. Haval. SYNTHESIS AND MOLECULAR DOCKING STUDIES OF NOVEL PYRIDINE-THIAZOLE-HYDRAZONE CONJUGATES AS ANTIMICROBIAL AND ANTIOXIDANT AGENTS. ECB. 2020; 9(7): 184-192.

Web Style

Mahesh B. Muluk, Pravin S. Patil, Sanghratna L. Kasare, Ravibhushan S. Kulkarni, Prashant P. Dixit, Prafulla B. Choudhari, Kishan P. Haval. SYNTHESIS AND MOLECULAR DOCKING STUDIES OF NOVEL PYRIDINE-THIAZOLE-HYDRAZONE CONJUGATES AS ANTIMICROBIAL AND ANTIOXIDANT AGENTS. https://www.eurchembull.com/?mno=47703 [Access: August 09, 2022].

AMA (American Medical Association) Style

Mahesh B. Muluk, Pravin S. Patil, Sanghratna L. Kasare, Ravibhushan S. Kulkarni, Prashant P. Dixit, Prafulla B. Choudhari, Kishan P. Haval. SYNTHESIS AND MOLECULAR DOCKING STUDIES OF NOVEL PYRIDINE-THIAZOLE-HYDRAZONE CONJUGATES AS ANTIMICROBIAL AND ANTIOXIDANT AGENTS. ECB. 2020; 9(7): 184-192.

Vancouver/ICMJE Style

Harvard Style

Mahesh B. Muluk, Pravin S. Patil, Sanghratna L. Kasare, Ravibhushan S. Kulkarni, Prashant P. Dixit, Prafulla B. Choudhari, Kishan P. Haval (2020) SYNTHESIS AND MOLECULAR DOCKING STUDIES OF NOVEL PYRIDINE-THIAZOLE-HYDRAZONE CONJUGATES AS ANTIMICROBIAL AND ANTIOXIDANT AGENTS. ECB, 9 (7), 184-192.

Turabian Style

Mahesh B. Muluk, Pravin S. Patil, Sanghratna L. Kasare, Ravibhushan S. Kulkarni, Prashant P. Dixit, Prafulla B. Choudhari, Kishan P. Haval. 2020. SYNTHESIS AND MOLECULAR DOCKING STUDIES OF NOVEL PYRIDINE-THIAZOLE-HYDRAZONE CONJUGATES AS ANTIMICROBIAL AND ANTIOXIDANT AGENTS. European Chemical Bulletin, 9 (7), 184-192.

Chicago Style

Mahesh B. Muluk, Pravin S. Patil, Sanghratna L. Kasare, Ravibhushan S. Kulkarni, Prashant P. Dixit, Prafulla B. Choudhari, Kishan P. Haval. "SYNTHESIS AND MOLECULAR DOCKING STUDIES OF NOVEL PYRIDINE-THIAZOLE-HYDRAZONE CONJUGATES AS ANTIMICROBIAL AND ANTIOXIDANT AGENTS." European Chemical Bulletin 9 (2020), 184-192.

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APA (American Psychological Association) Style

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