E-ISSN 2063-5346
 

Research Article 
ECB. 2021; 10(3): 179-185


NITROGEN RICH IMIDAZOLE-TRIAZOLOPYRIMIDINE HYBRIDS: CATALYST FREE SYNTHESIS, ANTIMICROBIAL and ANTITUBERCULAR STUDIES

Panchani N.M., Joshi H.S.

Abstract
Herein we have reported a simple, rapid and efficient synthesis of 7-(substituted phenyl)-5-(1H-imidazol-4-yl)-5,8-dihydro-[1,2,4]triazolo[4,3-a]pyrimidine derivatives. In the present study, PEG-400 was used as an alternative and green reaction solvent in the first step and n-butanol in the second step. The protocol proposed in this work offers advantages, such as common starting materials, simple work-up, shorter reaction time, high yield and absence of the catalyst. The structural elucidation of these compounds is based on mass, IR, 1H NMR and 13C NMR spectral data. All the synthesized compounds have been evaluated for their in vitro antimicrobial and antitubercular activity.

Key words: Absence of catalyst; Antitubercular activity; Imidazole; Pyrimidine; Triazole


 
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Pubmed Style

N.M. P, H.S J. NITROGEN RICH IMIDAZOLE-TRIAZOLOPYRIMIDINE HYBRIDS: CATALYST FREE SYNTHESIS, ANTIMICROBIAL and ANTITUBERCULAR STUDIES. ECB. 2021; 10(3): 179-185.


Web Style

N.M. P, H.S J. NITROGEN RICH IMIDAZOLE-TRIAZOLOPYRIMIDINE HYBRIDS: CATALYST FREE SYNTHESIS, ANTIMICROBIAL and ANTITUBERCULAR STUDIES. https://www.eurchembull.com/?mno=52226 [Access: September 25, 2022].


AMA (American Medical Association) Style

N.M. P, H.S J. NITROGEN RICH IMIDAZOLE-TRIAZOLOPYRIMIDINE HYBRIDS: CATALYST FREE SYNTHESIS, ANTIMICROBIAL and ANTITUBERCULAR STUDIES. ECB. 2021; 10(3): 179-185.



Vancouver/ICMJE Style

N.M. P, H.S J. NITROGEN RICH IMIDAZOLE-TRIAZOLOPYRIMIDINE HYBRIDS: CATALYST FREE SYNTHESIS, ANTIMICROBIAL and ANTITUBERCULAR STUDIES. ECB. (2021), [cited September 25, 2022]; 10(3): 179-185.



Harvard Style

N.M., P. & H.S, . J. (2021) NITROGEN RICH IMIDAZOLE-TRIAZOLOPYRIMIDINE HYBRIDS: CATALYST FREE SYNTHESIS, ANTIMICROBIAL and ANTITUBERCULAR STUDIES. ECB, 10 (3), 179-185.



Turabian Style

N.M., Panchani, and Joshi H.S. 2021. NITROGEN RICH IMIDAZOLE-TRIAZOLOPYRIMIDINE HYBRIDS: CATALYST FREE SYNTHESIS, ANTIMICROBIAL and ANTITUBERCULAR STUDIES. European Chemical Bulletin, 10 (3), 179-185.



Chicago Style

N.M., Panchani, and Joshi H.S. "NITROGEN RICH IMIDAZOLE-TRIAZOLOPYRIMIDINE HYBRIDS: CATALYST FREE SYNTHESIS, ANTIMICROBIAL and ANTITUBERCULAR STUDIES." European Chemical Bulletin 10 (2021), 179-185.



MLA (The Modern Language Association) Style

N.M., Panchani, and Joshi H.S. "NITROGEN RICH IMIDAZOLE-TRIAZOLOPYRIMIDINE HYBRIDS: CATALYST FREE SYNTHESIS, ANTIMICROBIAL and ANTITUBERCULAR STUDIES." European Chemical Bulletin 10.3 (2021), 179-185. Print.



APA (American Psychological Association) Style

N.M., P. & H.S, . J. (2021) NITROGEN RICH IMIDAZOLE-TRIAZOLOPYRIMIDINE HYBRIDS: CATALYST FREE SYNTHESIS, ANTIMICROBIAL and ANTITUBERCULAR STUDIES. European Chemical Bulletin, 10 (3), 179-185.