E-ISSN 2063-5346
 

Original Article 
ECB. 2014; 3(6): 555-558


CYTOTOXIC EVALUATION OF SUBSTITUTED BENZALDEHYDES

Felipe A. R. Rodrigues, Augusto C. A. Oliveira, Bruno C. Cavalcanti, Marcília P. Costa, Claudia Pessoa, Alessandra C. Pinheiro, Marcus V. N. de Souza.

Abstract
A series of fifty-four commercial aldehydes have been synthesized and evaluated for their activity against peripheral blood mononuclear
cells (PBMC) and four human cancer cell lines, exhibiting potent citotoxicity (IC50 ranging from 0.36 to 4.75 μg mL-1
). The structureactivity relationship (SAR) analysis indicated that the number, the positions and the type of substituents attached into the aromatic and
heteroaromatic ring are critical for the biological activity. The aldehydes 24, 26, 48 and 49 displayed a potent citotoxicity activity compared
to the reference drug doxorubicin being, therefore, this discovery important for the rational design of new compounds against cancer.

Key words: cytotoxicity, substituted aldehydes, drugs, SAR, glioblastoma, ovary, colon


 
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How to Cite this Article
Pubmed Style

Felipe A. R. Rodrigues, Augusto C. A. Oliveira, Bruno C. Cavalcanti, Marcília P. Costa, Claudia Pessoa, Alessandra C. Pinheiro, Marcus V. N. de Souza. CYTOTOXIC EVALUATION OF SUBSTITUTED BENZALDEHYDES. ECB. 2014; 3(6): 555-558.


Web Style

Felipe A. R. Rodrigues, Augusto C. A. Oliveira, Bruno C. Cavalcanti, Marcília P. Costa, Claudia Pessoa, Alessandra C. Pinheiro, Marcus V. N. de Souza. CYTOTOXIC EVALUATION OF SUBSTITUTED BENZALDEHYDES. https://www.eurchembull.com/?mno=57724 [Access: August 09, 2022].


AMA (American Medical Association) Style

Felipe A. R. Rodrigues, Augusto C. A. Oliveira, Bruno C. Cavalcanti, Marcília P. Costa, Claudia Pessoa, Alessandra C. Pinheiro, Marcus V. N. de Souza. CYTOTOXIC EVALUATION OF SUBSTITUTED BENZALDEHYDES. ECB. 2014; 3(6): 555-558.



Vancouver/ICMJE Style

Felipe A. R. Rodrigues, Augusto C. A. Oliveira, Bruno C. Cavalcanti, Marcília P. Costa, Claudia Pessoa, Alessandra C. Pinheiro, Marcus V. N. de Souza. CYTOTOXIC EVALUATION OF SUBSTITUTED BENZALDEHYDES. ECB. (2014), [cited August 09, 2022]; 3(6): 555-558.



Harvard Style

Felipe A. R. Rodrigues, Augusto C. A. Oliveira, Bruno C. Cavalcanti, Marcília P. Costa, Claudia Pessoa, Alessandra C. Pinheiro, Marcus V. N. de Souza (2014) CYTOTOXIC EVALUATION OF SUBSTITUTED BENZALDEHYDES. ECB, 3 (6), 555-558.



Turabian Style

Felipe A. R. Rodrigues, Augusto C. A. Oliveira, Bruno C. Cavalcanti, Marcília P. Costa, Claudia Pessoa, Alessandra C. Pinheiro, Marcus V. N. de Souza. 2014. CYTOTOXIC EVALUATION OF SUBSTITUTED BENZALDEHYDES. European Chemical Bulletin, 3 (6), 555-558.



Chicago Style

Felipe A. R. Rodrigues, Augusto C. A. Oliveira, Bruno C. Cavalcanti, Marcília P. Costa, Claudia Pessoa, Alessandra C. Pinheiro, Marcus V. N. de Souza. "CYTOTOXIC EVALUATION OF SUBSTITUTED BENZALDEHYDES." European Chemical Bulletin 3 (2014), 555-558.



MLA (The Modern Language Association) Style

Felipe A. R. Rodrigues, Augusto C. A. Oliveira, Bruno C. Cavalcanti, Marcília P. Costa, Claudia Pessoa, Alessandra C. Pinheiro, Marcus V. N. de Souza. "CYTOTOXIC EVALUATION OF SUBSTITUTED BENZALDEHYDES." European Chemical Bulletin 3.6 (2014), 555-558. Print.



APA (American Psychological Association) Style

Felipe A. R. Rodrigues, Augusto C. A. Oliveira, Bruno C. Cavalcanti, Marcília P. Costa, Claudia Pessoa, Alessandra C. Pinheiro, Marcus V. N. de Souza (2014) CYTOTOXIC EVALUATION OF SUBSTITUTED BENZALDEHYDES. European Chemical Bulletin, 3 (6), 555-558.