SYNTHESIS AND CYTOTOXIC ACTIVITY OF NOVEL
TETRAHYDROBENZO[b]THIOPHENE-DERIVED
HETEROCYCLES

Wagnat W. Wardakhan; Faten I. Hamed; Eman M. Samir

2022, Vol: 11, Issue: 4

11/4Current Issue Online First Archive Aims and Scope Abstracting & Indexing Most Accessed Articles Most Downloaded Articles Most Cited Articles

« Previous Article

Original Article

ECB. 2016; 5(3): 82-87

SYNTHESIS AND CYTOTOXIC ACTIVITY OF NOVEL TETRAHYDROBENZO[b]THIOPHENE-DERIVED HETEROCYCLES

Wagnat W. Wardakhan, Faten I. Hamed, Eman M. Samir.

Abstract
Series of thiophene, thiazole, and pyrimidine derivatives based on the ethyl 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate
starting material were synthesized, and cytotoxic activity of synthesized compounds was evaluated. Results showed that three compounds,
viz. (2)-2-(4-methyl-3-phenylthiazole-2(3H)-ylidenea-mino)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carbonitrile, ethyl 2-(6-amino-4-imino3-phenyl-2-thioxo-3,4-dihydropyrimidin-1(2H)-yl)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate, and 4-imino-3-phenyl-3,4,5,6,7,8-
hexahydrobenzo[4,5]-thieno[2,3-d]pyrimidine-2-thiol, were the most active towards MCF-7 (breast adenocarcinoma), NCI-H460 (nonsmall cell lung cancer), and SF-268 (CNS cancer), but they were not active towards normal fibroblasts human cell line (WI-38). The
toxicity of selected compounds against shrimp larvae was also studied.

Key words: Tetrahydrobenzo[b]thiophene, thiazole, pyrimidine, thieno[d]pyrimidine, cytotoxic activity

	ARTICLE TOOLS
	Abstract
	PDF Fulltext
	How to cite this article
	Citation Tools
	Related Records
	Articles by Wagnat W. Wardakhan Articles by Faten I. Hamed Articles by Eman M. Samir
	on Google
	on Google Scholar

How to Cite this Article

Pubmed Style

Wagnat W. Wardakhan, Faten I. Hamed, Eman M. Samir. SYNTHESIS AND CYTOTOXIC ACTIVITY OF NOVEL TETRAHYDROBENZO[b]THIOPHENE-DERIVED HETEROCYCLES . ECB. 2016; 5(3): 82-87.

Web Style

Wagnat W. Wardakhan, Faten I. Hamed, Eman M. Samir. SYNTHESIS AND CYTOTOXIC ACTIVITY OF NOVEL TETRAHYDROBENZO[b]THIOPHENE-DERIVED HETEROCYCLES . https://www.eurchembull.com/?mno=69286 [Access: August 09, 2022].

AMA (American Medical Association) Style

Wagnat W. Wardakhan, Faten I. Hamed, Eman M. Samir. SYNTHESIS AND CYTOTOXIC ACTIVITY OF NOVEL TETRAHYDROBENZO[b]THIOPHENE-DERIVED HETEROCYCLES . ECB. 2016; 5(3): 82-87.

Vancouver/ICMJE Style

Wagnat W. Wardakhan, Faten I. Hamed, Eman M. Samir. SYNTHESIS AND CYTOTOXIC ACTIVITY OF NOVEL TETRAHYDROBENZO[b]THIOPHENE-DERIVED HETEROCYCLES . ECB. (2016), [cited August 09, 2022]; 5(3): 82-87.

Harvard Style

Wagnat W. Wardakhan, Faten I. Hamed, Eman M. Samir (2016) SYNTHESIS AND CYTOTOXIC ACTIVITY OF NOVEL TETRAHYDROBENZO[b]THIOPHENE-DERIVED HETEROCYCLES . ECB, 5 (3), 82-87.

Turabian Style

Wagnat W. Wardakhan, Faten I. Hamed, Eman M. Samir. 2016. SYNTHESIS AND CYTOTOXIC ACTIVITY OF NOVEL TETRAHYDROBENZO[b]THIOPHENE-DERIVED HETEROCYCLES . European Chemical Bulletin, 5 (3), 82-87.

Chicago Style

Wagnat W. Wardakhan, Faten I. Hamed, Eman M. Samir. "SYNTHESIS AND CYTOTOXIC ACTIVITY OF NOVEL TETRAHYDROBENZO[b]THIOPHENE-DERIVED HETEROCYCLES ." European Chemical Bulletin 5 (2016), 82-87.

MLA (The Modern Language Association) Style

Wagnat W. Wardakhan, Faten I. Hamed, Eman M. Samir. "SYNTHESIS AND CYTOTOXIC ACTIVITY OF NOVEL TETRAHYDROBENZO[b]THIOPHENE-DERIVED HETEROCYCLES ." European Chemical Bulletin 5.3 (2016), 82-87. Print.

APA (American Psychological Association) Style

Wagnat W. Wardakhan, Faten I. Hamed, Eman M. Samir (2016) SYNTHESIS AND CYTOTOXIC ACTIVITY OF NOVEL TETRAHYDROBENZO[b]THIOPHENE-DERIVED HETEROCYCLES . European Chemical Bulletin, 5 (3), 82-87.

This is an open access journal which means that all content is freely available without charge to the user or his/her institution. Users are allowed to read, download, copy, distribute, print, search, or link to the full texts of the articles in this journal without asking prior permission from the publisher or the author. This is in accordance with the Budapest Open Access Initiative (BOAI) definition of open access. The articles in European Chemical Bulletin are open access articles licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc-sa/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.

Copyright � 2022 European Chemical Bulletin All Rights Reserved. Subject to change without notice from or liability to European Chemical Bulletin. For best results, please use Internet Explorer or Google Chrome	Contact Information European Chemical Bulletin Budapest, Near Széchenyi István tér, 1051 Hungary Email : editor@eurchembull.com

Contact Information

How to cite this article