E-ISSN 2063-5346
 

Original Article 
ECB. 2016; 5(3): 82-87


SYNTHESIS AND CYTOTOXIC ACTIVITY OF NOVEL TETRAHYDROBENZO[b]THIOPHENE-DERIVED HETEROCYCLES

Wagnat W. Wardakhan, Faten I. Hamed, Eman M. Samir.

Abstract
Series of thiophene, thiazole, and pyrimidine derivatives based on the ethyl 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate
starting material were synthesized, and cytotoxic activity of synthesized compounds was evaluated. Results showed that three compounds,
viz. (2)-2-(4-methyl-3-phenylthiazole-2(3H)-ylidenea-mino)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carbonitrile, ethyl 2-(6-amino-4-imino3-phenyl-2-thioxo-3,4-dihydropyrimidin-1(2H)-yl)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate, and 4-imino-3-phenyl-3,4,5,6,7,8-
hexahydrobenzo[4,5]-thieno[2,3-d]pyrimidine-2-thiol, were the most active towards MCF-7 (breast adenocarcinoma), NCI-H460 (nonsmall cell lung cancer), and SF-268 (CNS cancer), but they were not active towards normal fibroblasts human cell line (WI-38). The
toxicity of selected compounds against shrimp larvae was also studied.

Key words: Tetrahydrobenzo[b]thiophene, thiazole, pyrimidine, thieno[d]pyrimidine, cytotoxic activity


 
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Pubmed Style

Wagnat W. Wardakhan, Faten I. Hamed, Eman M. Samir. SYNTHESIS AND CYTOTOXIC ACTIVITY OF NOVEL TETRAHYDROBENZO[b]THIOPHENE-DERIVED HETEROCYCLES . ECB. 2016; 5(3): 82-87.


Web Style

Wagnat W. Wardakhan, Faten I. Hamed, Eman M. Samir. SYNTHESIS AND CYTOTOXIC ACTIVITY OF NOVEL TETRAHYDROBENZO[b]THIOPHENE-DERIVED HETEROCYCLES . https://www.eurchembull.com/?mno=69286 [Access: August 09, 2022].


AMA (American Medical Association) Style

Wagnat W. Wardakhan, Faten I. Hamed, Eman M. Samir. SYNTHESIS AND CYTOTOXIC ACTIVITY OF NOVEL TETRAHYDROBENZO[b]THIOPHENE-DERIVED HETEROCYCLES . ECB. 2016; 5(3): 82-87.



Vancouver/ICMJE Style

Wagnat W. Wardakhan, Faten I. Hamed, Eman M. Samir. SYNTHESIS AND CYTOTOXIC ACTIVITY OF NOVEL TETRAHYDROBENZO[b]THIOPHENE-DERIVED HETEROCYCLES . ECB. (2016), [cited August 09, 2022]; 5(3): 82-87.



Harvard Style

Wagnat W. Wardakhan, Faten I. Hamed, Eman M. Samir (2016) SYNTHESIS AND CYTOTOXIC ACTIVITY OF NOVEL TETRAHYDROBENZO[b]THIOPHENE-DERIVED HETEROCYCLES . ECB, 5 (3), 82-87.



Turabian Style

Wagnat W. Wardakhan, Faten I. Hamed, Eman M. Samir. 2016. SYNTHESIS AND CYTOTOXIC ACTIVITY OF NOVEL TETRAHYDROBENZO[b]THIOPHENE-DERIVED HETEROCYCLES . European Chemical Bulletin, 5 (3), 82-87.



Chicago Style

Wagnat W. Wardakhan, Faten I. Hamed, Eman M. Samir. "SYNTHESIS AND CYTOTOXIC ACTIVITY OF NOVEL TETRAHYDROBENZO[b]THIOPHENE-DERIVED HETEROCYCLES ." European Chemical Bulletin 5 (2016), 82-87.



MLA (The Modern Language Association) Style

Wagnat W. Wardakhan, Faten I. Hamed, Eman M. Samir. "SYNTHESIS AND CYTOTOXIC ACTIVITY OF NOVEL TETRAHYDROBENZO[b]THIOPHENE-DERIVED HETEROCYCLES ." European Chemical Bulletin 5.3 (2016), 82-87. Print.



APA (American Psychological Association) Style

Wagnat W. Wardakhan, Faten I. Hamed, Eman M. Samir (2016) SYNTHESIS AND CYTOTOXIC ACTIVITY OF NOVEL TETRAHYDROBENZO[b]THIOPHENE-DERIVED HETEROCYCLES . European Chemical Bulletin, 5 (3), 82-87.