SYNTHESIS OF CROSS-LINKED ALOE VERA POLYMER VIA 2-ACRYLAMIDE PROPANE SULPHONIC ACID: A NOVEL PHARMACEUTICAL EXCIPIENT

Abstract: By employing the catalyst PF6, this study presents the first instance of quasiliving free radical polymerization and hybridization of 2-acrylamido-2-methylpropane sulfonic acid, obviating the need for earlier acidic group protection. Nuclear electromagnetic resonance and gel-permeation chromatography-based analyses confirmed the sulfonated copolymers' diblock structure. Excellent film-forming qualities and notable solubility in organic solvents were demonstrated by the copolymers that were created, specifically poly(2-acrylamido-2-methylpropanesulfonic acid)-b-poly(methyl methacrylate) (PAMPS-b-PMMA) and poly(2-acrylamido-2-methylpropanesulfonic acid)-b-poly(2-hydroxyethylmethacrylate) (PAMPS-b-PHEMA). With an ion exchange capacity of 3.35 mmol H+/g, PAMPS-b-PHEMA was the most effective of these copolymer membranes; crosslinking was required to stop membrane deterioration under aqueous conditions. PAMPS-b-PMMA is insoluble in water but soluble in methanol and dichloromethane, as evidenced by its ion exchange abilities, which ranged from 0.58 as the relationship to 1.21 mmol H+/g.These results are consistent with variations in the molar concentration of PAMPS and the attributes of the secondary block of the copolymer.