PREPARATION AND EVALUATION OF KETOCONAZOLE NANOGEL FOR TOPICAL APPLICATION

Abstract: Seborrheic Dermatitis is a topical skin inflammatory disorder, characterized by yellow-grey scales and has significant negative effect on quality of life. It occurs in 1-3% of immunocompetent adults. The most common clinical symptoms of SD are erythema, scaling and itching on scalp, facial skin especially around nasolabial folds chest area, groin area. Topical use of keratolytic, corticosteroids, antifungal agents are generally preferred over oral drug therapy due to less systemic side effects. Ketoconazole is widely used antifungal agent available as shampoo, lotion, creams, gel and aerosol formulations. The objective of the present research is to create, describe, and assess the Ketoconazole nanogel. KTZ is a lipophilic drug with log P value of 4.35 like other lipophilic drugs it possess poor water solubility and has limited bioavailability after topical application. Nanoparticle drug delivery system helps in enhancing the bioavailability and overall therapeutic profile of lipophilic drugs. These are prepared by amalgamation of Nanoparticle system and hydrogel base. The main aim of this study was to formulate a Nanogel formulation of Ketoconazole drug and characterize it on the basis on particle size, Zeta potential, pH, rheological properties, spread ability and extrudability. Nanoparticles were prepared with mechanical dispersion technique and Carbopol 934P and 940 is used as a gelling agent and in the preparation nanogel. Additionally, they were examined for pH, spreadability, homogeneity, drug content, extrudability, viscosity, in-vitro release, and stabilities investigations. These were also assessed for FTIR investigations, TEM, and particle size measurements. The medication and polymer were compatible with one another during preparing, according to FTIR measurements. By adding F4 nanoparticles to a hydrogel basis that contained Carbopol 934 & 940 as a gelling agent. F2 composition had effective extrudability (7.3 g/cm3), spreadability (4.10 g/cm/sec), and an acceptable pH (6.1) with viscosity (850 cps). The F2 medication release pattern in vitro demonstrated an 83.87% release of drug in 12 hours.