Cancer is a major world public health problem, associated with chemotherapy treatments whose administration leads to other secondary problems. Oral cancer is one of the usual causes of mortality in world, with a five year survival rate of only 50%. The OC is generally treated primarily by surgery with or without adjuvant radiotherapy / or chemotherapy. But these therapy and treatments are generally shows major side effects like loss of hairs, loss of appetite, neurons functional loss etc. Nowadays natural products are leading candidates in treatment of oral cancer. There is a number of dietary supplements like fruits and vegetables that are rich in phytochemicals and provides a variety of antioxidants like vitamin A,C,E, Curcumin, NEEM, Green Tea, some medicinal Mushrooms. This article gives you a brief knowledge about how natural products can act in fighting against oral cancer and prevent oral cancer by less toxic effects and higher efficacy.