.

ISSN 2063-5346
For urgent queries please contact : +918130348310

ONE-POT ENVIRONMENT FRIENDLY SYNTHESIS OF IMINE DERIVATIVE OF FURFURAL AND ASSESSMENT OF ITS ANTIOXIDANT AND ANTIBACTERIAL POTENTIAL

Main Article Content

Miss Maria Abdullah Butt, Prof. Dr. Muhammad Nawaz Chaudhary, Prof. Dr. Sajid Rashid Ahmed, Dr. Muhammad Zaheer, Dr. Muhammad Naeem
» doi: 10.53555/ecb/2024.13.01.39

Abstract

In this study, an environment friendly, one-pot method is used to synthesize immine derivative (E)-8-((furan-2-ylmethylene)amino)-4-methyl-7-oxo-2-thiabicyclo[4.2.0]oct-4ene-5-carboxylic acid from renewable lignocellulosic biomass furfural and 7-ADCA. Furfural derived from lignocellulosic biomass plays an important role in this environment friendly approach. This process is based on the principles of green chemistry, especially the use of ethanol as a solvent reduces the environmental impacts associated with conventional synthetic methods. The chemicals and processes utilized, highlights a sustainable practice in pharmaceutical research and are aimed at using 7-aminodeacetoxy cephlospornic acid (7ADCA) and furfural for the synthesis of Schiff Base (FA). The synthesized imine derivative (FA) was characterized using various analytical techniques such as melting point, FT-IR, NMR and SEM. The derivative appeared to be a brown coloured fine powder having melting point 170°C and average particle size 450nm with agglomerated form and spherical shape. The yield was calculated to be 64%. Systematic screening of the synthesized imine showed promising antioxidant activity by phosphomolybdenum assay and In-Vitro antibacterial assay exhibited bactericidal activity against a variety of gram-positive and gram-negative bacteria. These studies not only appear to provide strategies for manufacturing sustainable products also promotes sustainable practices in pharmaceutical research and explores the ways in which furfural-derived imines can be used in pharmaceutical and materials science.

Article Details

SCImago Journal & Country Rank