Background: Intraoral soft tissue defects can be induced by various etiologies. Cleft palate and cleft alveolus are congenital defects that accompany bone defects. Oroantral fistula is often observed after tooth extraction in cases of severe sinus pneumatization. Tumor or trauma also shows various degrees of soft tissue defects. For the treatment of cleft palate sealing the communication between the oral cavity and the nasal cavity is essential for successful treatment. Salivary gland tumors are a rare group of complex, heterogonous histologies that are located in the parotid glands, submandibular glands, sublingual glands and minor salivary glands of the upper aerodigestive tract. Congenital epulis or congenital gingival granular cell tumor refers to an exophytic congenital tumor that arise from the alveolar ridge and has histologic features identical to those of granular cell tumors. Jaw tumors and cysts are relatively rare growths or lesions that develop in the jawbone or the soft tissues in the mouth and face. Jaw tumors and cysts sometimes referred to as odontogenic or nonodontogenic, depending on their origin can vary greatly in size and severity. For all these causes of intraoral lesions, over decades plastic surgeons have introduced many types of flaps for reconstruction of sealing such intraoral defects. In this brief review, we will highlight some of the most commonly met intraoral defects and some of the most commonly used flaps in their reconstruction.