Arthritis is derived from the Greek term “disease of the joints.” It is defined as an acute or chronic joint inflammation that often co-exists with pain and structural damage. Hereditary and acquired autoinflammatory illnesses have a direct correlation with several inflammasomes. Numerous autoimmune illnesses, including systemic lupus erythematosus (SLE), type 1 and type 2 diabetes, neurological disorders, and cancer, have been linked to excessive inflammasome activation. A frequent kind of systemic autoimmune illness that mostly affects synovial joints is rheumatoid arthritis (RA). Osteoarthritis (OA) is the most common form of arthritis that simultaneously affects the lives of elderly people as well as young individuals suffering post-traumatic injuries. Any articular joint in the body may be affected by this chronic inflammatory disease, but knees, hands, feet, and fingers are most frequently affected. Compared to RA, OA synovitis is more localized; in the knee, the suprapatellar pouch is the most prevalent location. While synovitis may only play a small part in the development of OA in some people, it plays a significant role in the destruction of joints in RA. Psoriasis is a multisystem, chronic inflammatory skin illness that most frequently affects the extensor surfaces of the elbows and knees. Blood and serological markers hold advantages over articular chemokines and radiology. Since the autoantibodies can be identified in pre articular phase in blood. Rheumatoid arthritis is allied with different autoantibodies including Rheumatoid factor (RF), Anti cyclic citrullinated peptide antibody (ACPA), Anti keratin antibody (AKA), Anti perinuclear factor (APF) and Anti-filaggrin antibody. Conventional radiography (CR) is currently regarded as the gold standard approach for evaluating structural damage. Radiography emphasizes the importance of cortical bone, which is visible on standard X-rays due to its calcium concentration. Ultrasound is an important tool in medical diagnostics. It is non-invasive and simple to perform, does not involve radiation, and requires extremely portable equipment. PET is used in conjunction with a structural imaging modality (most commonly CT) to generate detailed cross-sectional anatomical pictures on which functional information can be placed. Several studies have already demonstrated that PET can predict the onset of RA in patients without arthritis. Joint scintigraphy is a non-invasive technique for detecting and measuring joint inflammation. Skeletal scintigraphy is a more selective tool for detecting joint inflammation than radiography and is more sensitive than clinical examination.