This case study is about adverse reactions on covid vaccine, The coronavirus was officially named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) by the International Committee on Taxonomy of Viruses based on phylogenetic analysis. SARS-CoV-2 is believed to be a spillover of an animal coronavirus and later adapted the ability of human-tohuman transmission. Because the virus is highly contagious, it rapidly spreads and continuously evolves in the human population.some individuals experience few abnormal activites after getting vaccinated ,The purpose of this review artcle is to discuss about the hypersensitivity reactions occurred in a patient who took covid vaccination and the detailed study about adverse effects on covid vaccines and prevent the possible abnormal outcome after getting vaccinated for COVID-19. This case study will cover the complications occurring due to COVID-19 vaccines based on age factor, gender, brand, environmental status, weather, food interactions, drug interactions