Aim : The main aim of the study is to analyse the irrational use of PPIs and H2 Receptors antagonist that is prescribed without detecting any FDA Approved indications and to reduce the pill burden. Background: The incidence of improper use of PPIs varies from 40-70% in various studies. The prescriptions of proton pump inhibitors (ppis) have raised concern due to possible longterm adverse events caused by them . Conclusion: Irrational use of H2 receptor antagonists and PPIs increased with advanced age, increase in number of medications, multiple diagnoses and increased length of hospitalization. Effects and interactions were commonly encountered in many cases. Proper Guidelines for physicians and counseling for the patients is required in order to reduce overuse and to prevent long term adverse effects of the drugs.