Aim: The aim of the study was to examine the efficacy of a specific Ayurvedic treatment protocol in the management of pelvic pain in pelvic endometriosis. Materials & Methods: The non-interventional cohort study with pre-test and post-test design was conducted in 30 women aged between 18 and 45 years. The participants who were allocated for the study were observed to receive a specific Ayurvedic treatment protocol including Mṛdu Virecana (mild purgation therapy) followed by internal medications for 3 consecutive menstrual cycles. Visual analogue scale (VAS) scores were recorded at baseline and after each menstrual cycle consecutively for 3 months during the treatment and follow- up after one month. Quality of life (QoL) was recorded using Endometriosis Health Profile Questionnaire (EHP-30) at baseline and follow- up assessment was done one month after cessation of treatment. Results: Pelvic pain assessed with Visual analogue scale (VAS) scale at baseline and after each menstrual cycle during treatment for three months and at follow up were 9.96±0.17, 5±0.73, 1.43±0.15, 1.43±0.15, 1.43±0.15 respectively which was found to be statistically significant at P < 0.0125. The Quality of life (QoL) assessed with Endometriosis Health Profile Questionnaire (EHP-30), before treatment and after follow up was found to be 42.35±0.001 and 84.93±0.053 respectively which was statistically significant with P <0.05. Conclusion: The specific Ayurveda protocol was effective in the management of pelvic pain in pelvic endometriosis thereby improving the Quality of Life.