Self-medication is a public health concern because of drug misuse/abuse and its medical, social and psychological problems. Aim: Given the growing prevalence of self-medication, the present study aims to determine the prevalence and causes of self-medication among the age group from 25 to 45 years. Method: This cross-sectional study was conducted from 24 December 2022 to 18 April 2023, it was carried out by household survey. For this cross-sectional study, we performed in-person interviews in both urban and rural locations. Both urban and rural regions of Karnataka, Andhra Pradesh, Uttarakhand, Maharashtra, Tamil Nadu, Delhi, Kerala, Mumbai, Assam, Meghalaya and Dubai were used for the study. Results: The majority of subjects (32.3%) are between the ages of 25 to 36, followed by the age groups of 36 to 45(22.1%), 36 to 35 years (3.4%), 18-25 years (26.5%) and those over 45 years (8.0%). Out of all the volunteers, 60.5% were females and rest were males. 9.2% were housewives, 9.8% engineers, 20.4% students, 9.4% teachers, 7.6% professors, 5.8% IT workers. 80.3% of people stay at home while the rest in hostel. 78.4% of the subjects had no prior medical history, 8.0% had diabetes, and 4.6% had hypertension. Out of which, 6.2% of people purchase their own medications, 24.8% contact a chemist, 64.7% consult a doctor, and 0.2% take a nap when they are ill. Conclusion: Due to the adverse effects of self-medication, drug dependency, and microbial resistance and the relatively high prevalence of self-medication among students in this study, it would be advisable to organize awareness campaigns to further educate students about self-medication.