Background: Sandhigatavata is one among the Vatavyadhi (disease) mentioned in Ayurveda classics. Sandhigatavata can be compared with Osteoarthritis of contemporary medical science. Basti karma and Shasthikashali Pinda swedana are said to be the most effective treatment modalities to treat Vatavyadhi. Here an attempt was made to assess the effect Satavhaditaila matrabasti with and without Shasthikashaali pinda swedana in Sandhigatavata. Methods: It is a comparative clinical trial. The study was conducted on 30 patients divided into Group A and Group B having 15 patients each. Group A patients were treated with 80 ml of Shatavhaditaila matrabasti along with Shasthikashali Pinda swedana for 10 days. The assessment parameters were noted before the treatment and after follow up(60th day). To assess the results, un paired and paired t test statistical analysis methods were used.