Studies have shown that a UTI may impact the G-U system, from the kidneys' cortical renal tissue to the urethral meatus. Studies have also shown that hospital stays,costs, morbidity, and death are affected by the global phenomenon of antibiotic resistance. Therefore, we decided to evaluate and assess urine culture, prevalence, and drug sensitivity for UTI patients with DM and N-DM. We found that women showed a higher risk for UTI than men, regardless of DM status. Species like Klepsiella spp. and E. coli were the most common isolates in our study for both groups. These isolates showed moderate to poor resistance to at least one antibiotic tested. Antimicrobial drugs showed resistance in DM patients. All this suggests that continuous monitoring of bacterial strain sensitivity and resistance is required throughout DM with empirical UTI treatment. Thus, empirical use of nitrofurantoin, fluoroquinolones, and 1st generation cephlos (Cephalexin and Cefadroxil) may be necessary, but culture and sensitivity data are still required. Our study's findings must be confirmed by further longitudinal studies