The aim of the present study is to compare and evaluate the efficacy of oxygen releasing formula gel and chlorhexidine gel adjunct to scaling and root planing and scaling and root planing alone in patients with chronic mild-moderate periodontitis clinically and microbiologically in red complex bacteria (Porphyromonas gingivalis, Treponema denticola, and Tannerella forsythia). Materials and method: 10 Mild to moderate chronic periodontitis patients were selected. 3 sites of different quadrants were selected from each patient which summed up to the required sample size i.e., 30 sites (n=30). The quadrants were randomly allocated by using convenient sampling technique. (n-30) into three groups. GROUP A- Scaling and root planing was carried out as a stand-alone therapy. GROUP B- Scaling and root planing with application of chlorhexidine gel. GROUP C- Scaling and root planing with application of oxygen releasing formula gel. Clinical parameters (plaque index, gingival index, pocket probing depth, clinical attachment level) and level of red complex bacteria were assessed at base line and after three months of follow up. Results: Significant improvement in the clinical parameters (PI, GI, PPD, CAL) and microbiological count (P.g., T.f., T.d.) in oxygen gel group and chlorhexidine group in adjunct to SRP when compared to SRP alone from baseline to 3 months. Overall, no statistically significant difference was observed in comparison among all the three groups from baseline to 3 months except P.g.count which was statistically significant. Conclusion: Two of the gels i.e chlorhexidine gel and Blue m gel can be used as an reliable option or adjunctive to SRP, in the present study Blue m gel has shown to be fairly and coequally effective when compared to the chlorhexidine gel in treating mild to moderate periodontal pockets.