High demand of metal-free restorations led to the development of all ceramic restorations which are widely used in dentistry due to their excellent mechanical properties and favorable esthetics. Poor bonding of ceramics to resin cement leads to the usage of surface treatment methods like sandblasting, acid etching, and laser etching. Aim: To compare the effect of sandblasting with alumina particles and carbon dioxide laser surface treatment at different power outputs, 2W and 4W on the shear bond strength of Zirconia to resin cement. Methods: In this in vitro experimental study 20 monolithic zirconia discs of dimension 10*2 mm were prepared and divided into four groups based on surface treatment methods. Group 1 – No treatment was done and it served as a control group. Group 2 - Sandblasting with alumina particles. Group 3 - Carbon dioxide laser treatment at 2watt power. Group 4 - Carbon dioxide laser treatment at 4-watt power. Composite discs were prepared of dimension 6*2mm and then bonded with zirconia discs by resin cement. All the samples were subjected to a shear bond strength test. Results: The highest shear bond strength was obtained with carbon dioxide laser irradiation at 4W power, followed by irradiation at 2W power and sandblasting with Al2O3 particles. The lowest bond strength was observed in control group.