Background and Aims: Desflurane and Sevoflurane, having similar blood-gas co-efficients, are expected to demonstrate faster recovery from anesthesia. We conducted this study between Desflurane and Sevoflurane to evaluate and compare emergence, postoperative recovery and also their efficiency in maintaining stable intraoperative hemodynamics. Methods: This prospective, randomised, double-blinded study was conducted on 60 American society of Anesthesiologists (ASA) I and II patients, aged between 20 to 50, who underwent elective laparoscopic appendicectomy under general anesthesia. We followed institutional general anesthesia protocol with either 4% Desflurane (Group D=30 patients) or 1% Sevoflurane (Group S=30 patients). Intraoperative vitals and postoperative scoring for recovery were noted and SPSS version 17 was used for the statistical analysis. Results: Heart rate was comparable in both the groups; blood pressure was comparatively maintained in a lower range in sevoflurane group than desflurane group (p ≤0.05 during most of the intraoperative period), although not clinically significant. Group D patients showed earlier response to pain (9.4±2.2 vs 2.8±1.2; p<0.01), oral commands (11.9±2 vs 4.6±1.6; p<0.01), spontaneous eye opening (14.8 ±2.4 vs 6.6 ±1.9; p<0.01), handgrip (17 ±2.7 vs 8.6 ± 1.8; p<0.01). A full scoring in modified Aldrete scale was also achieved significantly earlier in desflurane group (p<0.01) compared to sevoflurane. Conclusion: Emergence and recovery is earlier with desflurane than sevoflurane, with similar intraoperative hemodynamics in patients undergoing laparoscopic appendicectomy.