Introduction: Osteoarthritis (OA) of the knee joint is a chronic, degenerative problem often associated with pain involving the affected joint, decreased range of motion, and deformity. OA of the knee joint affects about half of the population over the age of 60 years and mainly women, as it is mostly because of osteoporosis as a result of decreased bone mineral density. Aims: To ascertain more practical method among intra particular platelet rich plasma and proximal fibular osteotomy in treating medial compartment osteoarthritis, and to identify which of these two method gives better improvement in day to day activities and in pain management. Materials and Methods: a total of hundred female post menopausal patients with grade I and grade II osteoarthritis was selected. The present study was a hospital based cross sectional observational study. Result: Our study showed that in Intra Articular PRP Group, 14 (28.0%) patients had Grade 1 and 36 (72.0%) patients had Grade 2. In Proximal Fibular Osteotomy Group, 13 (26.0%) patients had Grade 1 and 37 (74.0%) patients had Grade 2. This was not statistically significant (p=0.8217). Conclusion: The study highlights that both the VAS scores and WOMAC scores were significantly better at 3 and 6 months after surgery. We concluded that proximal fibular osteotomy provides only short- term relief in patients of medial compartment knee osteoarthritis of knee in post-menopausal women.