An estimated 262 million people worldwide were diagnosed with asthma this year, and the disease will be responsible for 455,000 fatalities this year. The current study was based on the evaluation of anti-asthmatic potential of Myrica esculenta and Brahmic acid through anaphylactic micro shock model in guinea pig. It also estimated the levels of COX and LOX enzymes. Budesonide was obtained from Farmabios as gift sample.