Peptic ulcer is acid-induced injury of intestinal system that is generally situated in stomach or upper segment of duodenum. The present research was based on the antiulcer role of Tinospora cordifolia and Spinus wallichiana in cold restraint stress model. Leaves of Tinospora cordifolia and Pinus wallichiana were obtained from the Katihar region and Uttarakhand region, India. These were identified and authenticated by a botanist. Both the leaves were washed making dust-free and dried at room temperature or shade. Animal House, School of Pharmacy, Al-Karim University provided the Wistar rats of either sex weighing 130–160g. The animals were kept in good health, with room temperatures of 25°C and a 12-hour light/dark cycle. All the rats were divided into 6 groups (n=6) i.e., group 1 administered normal saline, group 2 administered Ranitidine (20mg/kg), group 3 administered T. cordifolia ethanolic leaves extract (TCELE) (200mg/kg, p. o.), group 4 administered T. cordifolia ethanolic leaves extract (TCELE) (400mg/kg, p. o.), group 5 administered Pinus wallichiana ethanolic leaves extract (PWELE) (200mg/kg, p. o.) and group 6 administered Pinus wallichiana ethanolic leaves extract (PWELE) (400mg/kg, p. o.) up to 15 days.