This present study was undertaken to study the comparison of the biochemical parameters of alcoholic liver disease and non-alcoholic liver disease and to determine the efficacy of treatment of alcoholic and non-alcoholic liver disease. Methodology:A hospital-based prospective observational study was conducted at Adesh Hospital, Bathinda for duration of 6 months on approximately 125 patients visiting the Department of Gastroenterology, Adesh Institute of Medical Sciences and Research, Adesh Hospital, Bathinda.Results:SGOT was high in 81(64.8%) patients and SGPT was high in 78 (62.4%) patients out of 125 patients.The association of level of SGOT, SGPT with diagnosis is highly significant with p-value (0.000). Conclusion:In the patients with alcoholic liver diseases the levels of SGOT and SGPT including other biochemical parameters were high as compared to the patients with non-alcoholic liver diseases and the drugs that were given to the patients were effective in the treatment of the diseases