Premature membrane rupture inducement is controversial. AIM OF THE STUDY - The study examined the efficacy and safety of low-dose vaginal Misoprostol and Dinoprostone gel for inducing labour in term pregnancies with an unfavourable cervix and intact membranes. MATERIALS AND METHODOLOGY - Prospective, single-center, comparative cohort study in a level 3 maternity unit in rural Western Maharashtra from December 2017 to June 2019 comparing vaginal misoprostol 50 μg every six hours (maximum 150 μg) and dinoprostone 10 mg, a slow-release vaginal insert, for 24 h (maximum 20 mg) for labour induction in preterm rupture of membranes. RESULTS - Dinoprostone greatly enhanced vaginal delivery. Misoprostol increased foetal heart rate caesareans. Misoprostol induction and labour were shorter than dinoprostone. Maternal and newborn outcomes were comparable. CONCLUSION: Preterm rupture of membranes labour induction with vaginal dinoprostone appears to be more successful for vaginal birth than misoprostol (50 μg).