Ayurveda, one of the oldest medical disciplines in the world, focuses on treating disease and promoting health in individuals. Most of the Dravya stated in Agrya Prakarana that "treatment with a single drug" is accorded paramount priority in Ayurveda. Aushadha, Ahara, and Vihara are discussed under the general category of a single medicine for promoting health and curing sickness in the classic discussion of Agrya sangraha. The article focuses mostly on the substances in the form of diet and single-drug medicine mentioned in Charaka Samhita and Astanga Sangraha from Agrya Aushadha. Bruhatrayee includes Agrya Aushadhi to prevent disease and maintain health. Charak Sutrasthana includes Agrya Aushadhi, Ashtang Hridayam Uttarsthan includes Agrya Aushadhi, and in Ashtang Sangraha Sutrasthana Agrya Sangraha. Agrya Dravya i.e. the drug which can be used as the first drug of choice for the treatment of disease. They are cost-effective, economical, easy to use, and safe. Though the concept of Agrya Sangraha remains the same in both Samhitas, there is certain differentiation noted in the literature of Charak Samhita and Ashtang Sangraha. This article concentrates on the distinctive aspects of each Samhitas, with a particular emphasis on dietary and single-drug features