Medicated oils prepared according to the process explained in Ayurvedic literatures like Shargandhara samhita are used for internal administration and local applications different ailments. Medicated oils are prepared with sesame oil processed with decoction of herbs and paste of herbs. Murivenna, is an Ayurvedic medicated oil used for acute injuries like contusions, fresh wounds and in fracture management. This is an attempt to understand the pharmaceutical, analytical, pharmacological and clinical aspects of Murivenna by doing a review of all relevant literature. Murivenna is not mentioned in in Brihattrayi and Laghutrayis. This formulation was first explained in Agastyamarma Sastra, a medicine textbook of Siddha medicine. The formulation available in Ayurveda Formulary of India is a modified form of above formulation. Murivenna was used for various ailments like fracture, dislocation, sprain, osteo arthritis, plantar fasciitis and also be prescribed as a rectal instillation medicine for inflamed hemorrhoids. There is a scope for future researches of this wonderful formulation by converting it in to patient friendly dosage forms. Murivenna can be converted in to other dosage forms like ointment, gel and transdermal anti-inflammatory and analgesic patches.