Sublingual drug delivery is a unique method of delivering drugs to the body. In this method, medications are administered by placing them under the tongue, where they dissolve and enter the bloodstream directly, avoiding first pass effect. This method of drug delivery has several advantages over other routes of administration, such as oral or injectable routes. One of the key benefits is its higher bioavailability, as the drug is absorbed directly into the bloodstream. This results in a rapid onset of action. Sublingual drug delivery also has a reduced risk of side effects, as the medication bypasses the digestive system, which can often cause unwanted reactions. Additionally, this method of delivery can also improve patient compliance, as it eliminates the need for injections or swallowing large pills. In this review article, various topics are included for instance, mechanism of action, advantages and disadvantages of route, ideal properties, factor affecting sublingual route, preparation of sublingual tablets, evaluation of formulation, future prospective and challenges. Despite its advantages, sublingual drug delivery also has limitations. The amount of medication that can be delivered through this route is limited, and some drugs are not suitable for sublingual delivery due to their properties. This review article aims to provide a comprehensive overview of sublingual drug delivery, including its mechanism of action, advantages and limitations, evaluation parameters, challenges and future prospective and recent development. By highlighting the potential of sublingual drug delivery, this review hopes to encourage further research and development in this area of drug delivery.