Low back pain is a common health problem and caused by various risk factors such as lack of exercises, smoking, changing lifestyle and poor quality of life. Remedies include pharmacotherapy, surgery and exercise therapy. Magnesium is an important nutrient that plays a major role in pain management by regulating the NMDA receptors in turn causing the muscles to relax. Methodology: This is a comparative study with and without transdermal Magnesium oils sprays along with exercises and electrotherapy are used in low back pain patients. The sample size is 30 participants aged 24-40 years, and the outcome measures include pain, Mg RBC levels, activities of daily living. Results: The results showed a significant improvement in pain and activities of daily living from day 0 to 45th day and 45th day to 90th day in both Group A and Group B. Discussion and Conclusion: Both treatment protocols significantly improved patients, with a greater improvement observed in Group A.