In this work, an attempt was made to synthesize chalcones N-[4-Chloro-2-(2- fluorobenzoyl)phenyl]-3-(substitutedphenyl)acrylamide derivatives by the condensation of aromatic aldehyde with N-[4-chloro-2-(2-fluorobenzoyl)phenyl]acetamide under basic conditions by using both conventional and microwave irradiation methods. A simple condensation of aromatic aldehyde and N-[4-Chloro-2-(2-fluorobenzoyl)phenyl]acetamide using sodium methoxide as a base was carried out for the study. The synthesized compounds were characterized for IR, 1H NMR, 13C NMR and mass spectral analysis. It was observed that completion of a reaction occurred in 10-12 min by microwave irradiation method and in 10-12 hr by conventional method. Finally, it was observed that microwave irradiation method is more convenient, rapid and eco-friendly as compare to conventional method. The reaction time has been brought down from hours to seconds with improved yield as compared to conventional method.